DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and MARK4

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001186796.1	Gene:	MARK4 / 57787	HGNCID:	13538	Length:	752	Species:	Homo sapiens

Alignment Length:	635	Identity:	266/635 - (41%)
Similarity:	356/635 - (56%)	Gaps:	128/635 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PGPNTSISTTATPPSAAAQNVGGCFGSS--GGR------SSPKFQSYVNGNGYGVYKIIKTLGKG 72
            ||.:.:..|..|..|..:.:.|..:.|.  |.|      |.|:.|.:|     |.|::::|:|||
Human     9 PGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHV-----GNYRLLRTIGKG 68

  Fly    73 NFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYL 137
            ||||||||.|:.||||||||:||||.||..:.|||:|||.|||.|||||||:|.:|||:|:||||
Human    69 NFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYL 133

  Fly   138 VMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIA 202
            ||||.|.||:|:|||.:|||:|::||..|||:|||:.|||.|:||||||||||||||.:..:|||
Human   134 VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIA 198

  Fly   203 DFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKE 267
            |||||..|...:.|:||||||||||||||:||||.|||||.|||||:|||||||||||||.||||
Human   199 DFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE 263

  Fly   268 LRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPM 332
            ||:||||||||||:|:|.:|||::|:||||||.:|.:|..:|.|:|||:||| |..|:|:.|...
Human   264 LRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYE-GEELKPYTEPEE 327

  Fly   333 DLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTAM 397
            |..|..|:.::..||:...::::||.:||::::..||:||.    |.|   |:.|.      ...
Human   328 DFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLG----RKT---EEGGD------RGA 379

  Fly   398 PG--SSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLAN-----ALTPLPLTP--- 452
            ||  .:|:..|....|.|.|      .|.|.:.....|......|...     ..:|.||.|
Human   380 PGLALARVRAPSDTTNGTSS------SKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRS 438

  Fly   453 --------------PPKKYICCSA--------------SKAANPRRSE-----------PSSIPQ 478
                          |.:|..|.:|              |.|.||.::|           |:::|.
Human   439 PTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPP 503

  Fly   479 SAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDS 543
            |.|.:         :.|.:..:|..|....|          :......:|...|.||
Human   504 SMMTR---------RNTYVCTERPGAERPSL----------LPNGKENSSGTPRVPP-------- 541

  Fly   544 TSTPLKVLKLVASNSQTPPSTENTNRPTRVGFFSKLS-ARFVRRSLHKGE 592
             ::|       :|:|..|||.|.          |:|: ...:|.:.|.|:
Human   542 -ASP-------SSHSLAPPSGER----------SRLARGSTIRSTFHGGQ 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	177/250 (71%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	177/250 (71%)
MARK4	NP_001186796.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		6/26 (23%)
		STKc_MARK	58..310	CDD:270974	177/251 (71%)
		S_TKc	59..310	CDD:214567	177/250 (71%)
		UBA_MARK3_4	328..370	CDD:270590	13/45 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..614		46/240 (19%)
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810