DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and sik2b

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_696325.5	Gene:	sik2b / 567919	ZFINID:	ZDB-GENE-071012-1	Length:	896	Species:	Danio rerio

Alignment Length:	585	Identity:	214/585 - (36%)
Similarity:	306/585 - (52%)	Gaps:	106/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRL 125
            |.|.|.:||||||||.||||.|..|..|||||:||||.|:.:..:|:||||.|||.|:||:|::|
Zfish    20 GFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHIIKL 84

  Fly   126 LQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAEN 190
            .||:|::..||||.||...||:|:||.|:||:.|.:||..|.|::||:||||:::||||||||||
Zfish    85 YQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNIVHRDLKAEN 149

  Fly   191 LLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVS 255
            ||||..|.:|||||||...|:...||.|:||||||||||:|.|::|.||::|.||:|||||.||.
Zfish   150 LLLDGHMNIKIADFGFGNFFQSGKPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVC 214

  Fly   256 GSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMG--- 317
            |:|||||.:|..||.|||.|::|:||:::.:||.|||:.|||:|::|.|:..:...:|:.|.
Zfish   215 GALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKRLSIGQIKEHKWMVMEVPV 279

  Fly   318 -----YEQGN----GLRPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLD 373
                 |:|..    |:..:.|:.        |.|:.::|.......:||:|:.::.....|.||
Zfish   280 QRPMLYQQTTEGEAGVGEYNEQV--------LRLMHSLGIDQHKTVESLQNKSYNHFAAIYYLL- 335

  Fly   374 VAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMA 438
            |.:.::..||             .|...|:......|:....|.......:.|.    .|:.|..
Zfish   336 VERLKAHRCS-------------FPVEPRLDARQRRPSTIAEQTLVKASSAAPQ----VSLLPQN 383

  Fly   439 PRLANALTPLPLTPPPKKYICCSASKAANPRRSEPS-SIPQSA-------MPKKGVGSPVDVKTT 495
            .||        |.||            |.|:.|..| :.|||:       |.::.||:| .:...
Zfish   384 VRL--------LRPP------------AVPQTSADSFTFPQSSCAAEHSLMEEEEVGTP-KINGC 427

  Fly   496 LLSAQRKLAVNQKLTSASHQIRSPITQSPSQASEC-------TRTPPTHFEMLDSTSTPLKVLKL 553
            :|.....:||.:  :|||         |||...|.       |..|.|.    |..:......:.
Zfish   428 MLDPLPPVAVRK--SSAS---------SPSNMMETSIDEGIETEEPDTE----DDHTHVFNAYQT 477

  Fly   554 VASNSQTPPSTENTNRPTRVGFFSKL------------SARFVRRSLHKGEKDIS--EQGRNLTK 604
            .....:....:|.||:|..:....||            .:.:...|:|   .|:|  |.|.:|.:
Zfish   478 ARFGQRRHTLSEVTNQPGIITSGGKLFSMGHNPSLGSVDSEYDMGSMH---SDLSLLEDGPSLNE 539

Fly 605 604
Zfish 540 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	145/250 (58%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	145/250 (58%)
sik2b	XP_696325.5	STKc_SIK	21..273	CDD:270973	145/251 (58%)
		S_TKc	22..273	CDD:214567	145/250 (58%)
		UBA_SIK2	299..343	CDD:270592	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770