DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and PRKCI

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_002731.4	Gene:	PRKCI / 5584	HGNCID:	9404	Length:	596	Species:	Homo sapiens

Alignment Length:	274	Identity:	84/274 - (30%)
Similarity:	150/274 - (54%)	Gaps:	26/274 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RSSPKFQSYVNGNGYGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNT------IAR 104
            |.|.|..|.:   |...:.:::.:|:|::|||.|.....|.|..|:|::.|..:|.      :..
Human   240 RESGKASSSL---GLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQT 301

  Fly   105 QK-LYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQ 168
            :| ::.:.:     |||.:|.|....::|..|:.|:|||:||:|..::.:..::.|..||....:
Human   302 EKHVFEQAS-----NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAE 361

  Fly   169 LVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGF-STTFEPKAPLETFCGSPPYAAPELFR 232
            :..|:.|.|.:.|::||||.:|:|||.:..:|:.|:|. .....|.....||||:|.|.|||:.|
Human   362 ISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 426

  Fly   233 GKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDR---------VLRGKYRVPYYVSIECE 288
            |:.| |..||.|:|||:::.:::|..|||.....:..|:         :|..:.|:|..:|::..
Human   427 GEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490

  Fly   289 SLIRKFLVLNPTQR 302
            |:::.||..:|.:|
Human   491 SVLKSFLNKDPKER 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	79/257 (31%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	79/257 (31%)
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Regulatory domain	2..253		5/15 (33%)
		Required for interaction with RAB2	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134
		C1_1	141..191	CDD:365894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..246		3/5 (60%)
		STKc_aPKC_iota	233..596	CDD:270769	84/274 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910