DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and sik1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001119855.1	Gene:	sik1 / 553465	ZFINID:	ZDB-GENE-030131-9446	Length:	811	Species:	Danio rerio

Alignment Length:	569	Identity:	213/569 - (37%)
Similarity:	296/569 - (52%)	Gaps:	110/569 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GVYKIIKTLGKGNFAKVKLAIHLPTG-----------REVAIKLIDKTALNTIARQKLYREVNIM 114
            |.|:||:||||||||.||||.|..|.           .:||||:||||.||:...:|:||||.||
Zfish    24 GFYEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFMQVAIKIIDKTRLNSANLEKIYREVQIM 88

  Fly   115 KKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSK 179
            |.||||:|::|.||:|::..||:|.||...||:|:||..||||.|.:||..|.|:::|::|||..
Zfish    89 KLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLTSNGRMSENEARKKFWQILTAVDYCHRH 153

  Fly   180 SIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSW 244
            .|||||||.||||||..|.:|:|||||...:....||.|:||||||||||:|.||:|.||::|.|
Zfish   154 HIVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIW 218

  Fly   245 SLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVM 309
            |||||||.||.|||||||.:|..||.||..|::|:|:::|.:||:||||.||::|.:|.:::.:.
Zfish   219 SLGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFFMSQDCENLIRKMLVVDPAKRITIAQIK 283

  Fly   310 ADRWINMGYEQGNGLRPFQEKPMDLHDVNR---------LSLLSNMGHKPRDVEQSLKNQK---F 362
            ..||:     ..:...|.|...:.|.|.|.         |.::..:|...:...:||:|..   |
Zfish   284 QHRWM-----LADPSAPHQTLSLSLTDYNSNLGDYSEPVLGIMQTLGIDRQRTVESLQNSSYNHF 343

  Fly   363 DDIYCTYMLLD-VAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTP 426
            ..||  |:||: |.:.||...|.:.|:..:.:.||.                        |.|||
Zfish   344 SAIY--YLLLERVKEHRSQQISRQCGAWNQRSRTAS------------------------DSSTP 382

  Fly   427 NRPAATSIRPMAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGVGSPVD 491
            .     .|...:....|:..|:             |:|...|..|| ....|..:.:: |..||:
Zfish   383 E-----VIMESSDSFRNSAFPV-------------ATKVNAPIHSE-MECEQGGLFQR-VVCPVE 427

  Fly   492 VKTTLLSAQRKLAVNQKL-TSASHQIRSPITQSPSQASE---CTRTPPTHFEMLDSTSTPLKVLK 552
            .....|...|.::.|..| |:.|.::|      |....|   ..:..|.|   |.||::....|.
Zfish   428 ASLNGLLWNRSISPNSLLETTISEEVR------PHDLEEEEGILQVQPPH---LPSTTSRRHTLA 483

  Fly   553 LVAS---NSQTPP-----------------STENTNRPTR--VGFFSKL 579
            .|::   :..:||                 |:.|||.|..  ||.||.|
Zfish   484 EVSTSRFHQCSPPCIVVSPSDGASSDSCLKSSSNTNPPLSPVVGDFSSL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	144/261 (55%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	144/261 (55%)
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	144/262 (55%)
		S_TKc	26..288	CDD:214567	144/261 (55%)
		UBA_SIK1	309..358	CDD:270591	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770