DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and MARK1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001273053.1	Gene:	MARK1 / 4139	HGNCID:	6896	Length:	796	Species:	Homo sapiens

Alignment Length:	693	Identity:	281/693 - (40%)
Similarity:	384/693 - (55%)	Gaps:	127/693 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AANTNKTTDKENDPGPNTSISTTATP-----PSAAAQNVGGCFGSSGGRSSPKFQSYVNGNGYGV 62
            :|.|...|..|.|...:||:.....|     .|::.||:..|..|.  .|:...|.::     |.
Human     2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSI--TSATDEQPHI-----GN 59

  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQ 127
            |::.||:|||||||||||.|:.||||||:|:||||.||..:.|||:|||.|||.|||||||:|.:
Human    60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 124

  Fly   128 VIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLL 192
            |||:|:||||||||.||||:|:|||.:|||:|::||..|||:|||::|||.|.||||||||||||
Human   125 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLL 189

  Fly   193 LDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGS 257
            ||..|.:||||||||..|.....|:||||||||||||||:||||.|||||.|||||:||||||||
Human   190 LDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS 254

  Fly   258 LPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGN 322
            |||||.||||||:||||||||:|:|:|.:||:|::|.|||||.:|.||..:|.|||:|:|:|: .
Human   255 LPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEE-E 318

  Fly   323 GLRPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKP---------- 377
            .|:|:.|...|.:|..|:.::..||....::..:|.|||:|::..||:||....|
Human   319 ELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSS 383

  Fly   378 -----RSTACSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTPN---------R 428
                 ||...|:.:.|:.:.     |...::...|:|..   .|..|: |.:.|:         |
Human   384 GNLCQRSRPSSDLNNSTLQS-----PAHLKVQRSISANQ---KQRRFS-DHAGPSIPPAVSYTKR 439

  Fly   429 PAATSI---------RPMAPRLANA-------LTPLPLTPPPKK--------------------- 456
            |.|.|:         :.:|.:|.:.       :|..||..|.:|
Human   440 PQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSSTIPSNNVYSGGSMARRNT 504

  Fly   457 YIC--------------------CSASKAANPRRSEPSSIPQSAMPK--KGV---GSPVDVKTTL 496
            |:|                    .|.|..::...|..|::| ||.|:  |.:   |.|:.|....
Human   505 YVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVP-SARPRHQKSMSTSGHPIKVTLPT 568

  Fly   497 L----SAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLKVLKLVASN 557
            :    .|.|..:..|::.:||....|..|.:|.:    ||.|.............|:..:.||.|
Human   569 IKDGSEAYRPGSTTQRVPAASPSAHSISTATPDR----TRFPRGSSSRSTFHGEQLRERRSVAYN 629

  Fly   558 SQTPPST--------ENTNRPTRVGFFSKLSARFVRRSLHKGE 592
            .  ||::        .:..|.|..|..||::::||||...:||
Human   630 G--PPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	179/250 (72%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	179/250 (72%)
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		10/37 (27%)
		STKc_MARK	59..311	CDD:270974	179/251 (71%)
		S_TKc	60..311	CDD:214567	179/250 (72%)
		UBA_MARK1	331..371	CDD:270588	13/39 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..495		22/126 (17%)
		MARK1-3_C	697..794	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910