DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and mark3a

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_021336197.1	Gene:	mark3a / 334300	ZFINID:	ZDB-GENE-030131-6232	Length:	746	Species:	Danio rerio

Alignment Length:	677	Identity:	269/677 - (39%)
Similarity:	370/677 - (54%)	Gaps:	129/677 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ISTTATP-PSAAAQNVGGCFGSSGGRSSPKFQSY-------VNGNG-------YGVYKIIKTLGK 71
            :|||..| |:...:.......:..|||....:|.       .:|:|       .|.|:::||:||
Zfish     1 MSTTRAPLPTVNERKAENHTTNGHGRSEVTSRSVRSSGRNRNSGSGLDDVHPVIGNYRLLKTIGK 65

  Fly    72 GNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLY 136
            |||||||||.|:.||.|||||:||||.||..:.|||.|||.|||.|||||||:|.:|||:|:||:
Zfish    66 GNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLF 130

  Fly   137 LVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKI 201
            |||||.||||:|:|||.:|||:|::||..|||:|||::|||.|.||||||||||||||..|.:||
Zfish   131 LVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKI 195

  Fly   202 ADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLK 266
            ||||||..|...:.|:||||||||||||||:||||.|||||.|||||:|||||||||||||.|||
Zfish   196 ADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK 260

  Fly   267 ELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKP 331
            |||:||||||||:|:|:|.:||:|:::||||||.:|.:|..:|.:||||.|:|. :.|:||.|..
Zfish   261 ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFED-DELKPFTEPD 324

  Fly   332 MDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYML-----------------LDVAKPRS 379
            .|:.|..|:.::..||.....:.:||....:|::...|:|                 |.|||.|.
Zfish   325 ADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLLLGRKTHEEVSDSSSNSNLSVAKTRP 389

  Fly   380 TA----------------CSEKSGSSFRETP-------TAMPGSSRIPVPIAAPNVTISQVTFAL 421
            ::                .|.:|..|.|.:.       .|:..|.|: ||:.|.: .:.|....:
Zfish   390 SSEMNSQSPSHLKVQRSISSSESRKSRRHSEQVGVVANNALSNSKRV-VPVTADS-EVKQEGGVI 452

  Fly   422 DKSTPNRPAATSIRPMAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGV 486
            .:..||.      .|.:|.|.||..|               :|...|.|.:.:||..:.:  .|.
Zfish   453 ARKLPNH------SPPSPLLGNANNP---------------NKTEIPDRKKGNSITSNNI--SGS 494

  Fly   487 GSPVDVKTTLLSAQR----KLAV--NQKLTSASHQIRSPITQSPSQASECTRTPPT--------- 536
            || :..:.|.:..:|    :|:|  |.|..|.|   .||.::.|..::....|..|
Zfish   495 GS-MSRRNTYVCTERNNTDRLSVIPNGKENSVS---LSPSSRDPGASTHSISTSVTPDKTRFPRG 555

  Fly   537 -------HFEMLD-----------STSTPLKVLKLVASNSQTPPSTENTNRPTRVGFFSKLSARF 583
                   |.::.|           |.:.|..  :..|:|..|..:::.|.|.....|..::|..|
Zfish   556 SASRSTFHGQVRDRRTATYNGPPASPAQPRS--RANANNLLTKLTSKLTRRNMSFRFSKRVSTEF 618

  Fly   584 VRRSLHKG---------EKDISEQGRN 601
            .|....:|         :||..:.|::
Zfish   619 ERSGRFEGSSRHVSGDQQKDEGKDGKD 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	176/250 (70%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	176/250 (70%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	176/251 (70%)
		UBA_like_SF	326..368	CDD:328731	10/41 (24%)
		MARK1-3_C	647..744	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910