Protein Alignment KP78b and mark3a

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_021336197.1
• Gene: mark3a / 334300
• ZFINID: ZDB-GENE-030131-6232
• Length: 746
• Species: Danio rerio
• Alignment Length: 680
• Identity: 272/680 - (40%)
• Similarity: 371/680 - (54%)
• Gaps: 135/680 - (19%)

  Fly    22 ISTTATP-PSAAAQNVGGCFGSSGGRSSPKFQSY-------VNGNG-------YGVYKIIKTLGK 71
            :|||..| |:...:.......:..|||....:|.       .:|:|       .|.|:::||:||
Zfish     1 MSTTRAPLPTVNERKAENHTTNGHGRSEVTSRSVRSSGRNRNSGSGLDDVHPVIGNYRLLKTIGK 65

  Fly    72 GNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLY 136
            |||||||||.|:.||.|||||:||||.||..:.|||.|||.|||.|||||||:|.:|||:|:||:
Zfish    66 GNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLF 130

  Fly   137 LVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKI 201
            |||||.||||:|:|||.:|||:|::||..|||:|||::|||.|.||||||||||||||..|.:||
Zfish   131 LVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKI 195

  Fly   202 ADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLK 266
            ||||||..|...:.|:||||||||||||||:||||.|||||.|||||:|||||||||||||.|||
Zfish   196 ADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK 260

  Fly   267 ELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKP 331
            |||:||||||||:|:|:|.:||:|:::||||||.:|.:|..:|.:||||.|:|. :.|:||.|..
Zfish   261 ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFED-DELKPFTEPD 324

  Fly   332 MDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYML-----------------LDVAKPRS 379
            .|:.|..|:.::..||.....:.:||....:|::...|:|                 |.|||.|.
Zfish   325 ADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLLLGRKTHEEVSDSSSNSNLSVAKTRP 389

  Fly   380 TA----------------CSEKSGSSFRETP-------TAMPGSSRIPVPIAAPNVTISQVTFAL 421
            ::                .|.:|..|.|.:.       .|:..|.|: ||:.|.: .:.|....:
Zfish   390 SSEMNSQSPSHLKVQRSISSSESRKSRRHSEQVGVVANNALSNSKRV-VPVTADS-EVKQEGGVI 452

  Fly   422 DKSTPNRPAATSIRPMAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGV 486
            .:..||.      .|.:|.|.||..|               :|...|.|.:.:||..:.:  .|.
Zfish   453 ARKLPNH------SPPSPLLGNANNP---------------NKTEIPDRKKGNSITSNNI--SGS 494

  Fly   487 GSPVDVKTTLLSAQR----KLAV--NQKLTSAS------------HQIRSPITQSPSQ-----AS 528
            || :..:.|.:..:|    :|:|  |.|..|.|            |.|.:.:|...::     ||
Zfish   495 GS-MSRRNTYVCTERNNTDRLSVIPNGKENSVSLSPSSRDPGASTHSISTSVTPDKTRFPRGSAS 558

  Fly   529 ECT--------RT-----PPTHFEMLDSTSTPLKVLKLVASNSQTPPSTENTNRPTRVGFFSKLS 580
            ..|        ||     ||.      |.:.|..  :..|:|..|..:::.|.|.....|..::|
Zfish   559 RSTFHGQVRDRRTATYNGPPA------SPAQPRS--RANANNLLTKLTSKLTRRNMSFRFSKRVS 615

  Fly   581 ARFVRRSLHKG---------EKDISEQGRN 601
            ..|.|....:|         :||..:.|::
Zfish   616 TEFERSGRFEGSSRHVSGDQQKDEGKDGKD 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	176/250 (70%)
		UBA_MARK_Par1	335..373	CDD:270522	9/54 (17%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	176/251 (70%)
		UBA_like_SF	326..368	CDD:473871	10/41 (24%)
		MARK1-3_C	647..744	CDD:213381