Protein Alignment KP78b and Smok2a

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001178548.2
• Gene: Smok2a / 292316
• RGDID: 1565233
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 157/532 - (29%)
• Similarity: 256/532 - (48%)
• Gaps: 120/532 - (22%)

  Fly    40 FGSSGGRSSPKFQSYVNGNG-----YGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTAL 99
            |||.  |.|.:.:|  .|:.     ...|.::.|:|.|..|.||||:|..||..||:|::
  Rat     3 FGSK--RESERLRS--QGSSCTESFCSQYLVLNTIGHGFHAAVKLAVHRLTGTPVAVKML----- 58

  Fly   100 NTIAR----QKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRER 160
              :.|    |::..||.||.::||||||.|:|||::|:..||:||...|.:|::::.:.|.::|.
  Rat    59 --LKRQQWCQQVTSEVEIMMRINHPNIVSLIQVIDTEKITYLIMELAKGNQLYSHIKEAGHLQED 121

  Fly   161 DARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPY 225
            :||.:||||:||:.|||.:.|:|||||.:|||:|.:.::||.|||.:|...|...|.|..|:..:
  Rat   122 EARGIFRQLLSAVGYCHEEGIIHRDLKPDNLLVDTKGRIKIIDFGSATQVRPGQKLRTPYGTYAF 186

  Fly   226 AAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESL 290
            :||||..||.|.||:||.|:|||:||.:..|.:||:..::..||.:::.|.|.||..:|.|.:.|
  Rat   187 SAPELLLGKFYEGPKVDVWALGVILYYMTVGKVPFEAASIPLLRRQIVLGTYVVPPGLSEELQDL 251

  Fly   291 IRKFLVLNPTQRTSLSAVMADRWINM---GYEQG-NGLRPFQEKPMDLHDVNRLSLLSNMGHKPR 351
            :...|.:|..||.::..::...|:.:   |:.|. ..|.|.:..|..|.      .:.::|.:.:
  Rat   252 LSLLLKVNSQQRPTIPDLLTHPWLKIDSEGFPQPCKELIPLRPDPAILR------AMQDIGFEAQ 310

  Fly   352 DVEQSLKNQKFDDIYCTYMLLDV------------------------------------AKPR-S 379
            :|:.||..:||:.....|.||:.                                    ::|| .
  Rat   311 EVKDSLDQKKFNQSMACYYLLEKQALQECDNPTRPHPCMTPFPTLDYPATSVRGLRSRGSEPRWL 375

  Fly   380 TACSEKSGSSFRETPT-------AMPGSSRIPVPIAAPNV------TISQVTFAL---------- 421
            .:.|:..||...:||:       :.||.........||.|      :||...|:.
  Rat   376 GSSSDSQGSDLGQTPSHRLVKRASWPGGLLCRPRQIAPTVELTHRISISDPCFSSVHSRGKKTIN 440

  Fly   422 DKSTPNRPA-ATSIRPMAPRLANALTPLPLTPPPKKY-------------ICCSASKAANPRRSE 472
            .:||.::.: :..::|:|.|           |.||::             :||..     |.|.:
  Rat   441 TESTEDKSSDSAEVKPVASR-----------PWPKRFRGWLKNIRNGLMNLCCCI-----PSRKK 489

  Fly   473 PSSIPQSAMPKK 484
            |.......:|:|
  Rat   490 PPLGHNRVVPQK 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	104/254 (41%)
		UBA_MARK_Par1	335..373	CDD:270522	8/37 (22%)
Smok2a	NP_001178548.2	STKc_AMPK-like	26..274	CDD:270905	104/254 (41%)
		UBA_MARK_Par1	294..333	CDD:270522	11/44 (25%)