DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and Smok2a

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001178548.2	Gene:	Smok2a / 292316	RGDID:	1565233	Length:	501	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	158/536 - (29%)
Similarity:	254/536 - (47%)	Gaps:	128/536 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FGSSGGRSSPKFQSYVNGNG-----YGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTAL 99
            |||.  |.|.:.:|  .|:.     ...|.::.|:|.|..|.||||:|..||..||:|::
  Rat     3 FGSK--RESERLRS--QGSSCTESFCSQYLVLNTIGHGFHAAVKLAVHRLTGTPVAVKML----- 58

  Fly   100 NTIAR----QKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRER 160
              :.|    |::..||.||.::||||||.|:|||::|:..||:||...|.:|::::.:.|.::|.
  Rat    59 --LKRQQWCQQVTSEVEIMMRINHPNIVSLIQVIDTEKITYLIMELAKGNQLYSHIKEAGHLQED 121

  Fly   161 DARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPY 225
            :||.:||||:||:.|||.:.|:|||||.:|||:|.:.::||.|||.:|...|...|.|..|:..:
  Rat   122 EARGIFRQLLSAVGYCHEEGIIHRDLKPDNLLVDTKGRIKIIDFGSATQVRPGQKLRTPYGTYAF 186

  Fly   226 AAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESL 290
            :||||..||.|.||:||.|:|||:||.:..|.:||:..::..||.:::.|.|.||..:|.|.:.|
  Rat   187 SAPELLLGKFYEGPKVDVWALGVILYYMTVGKVPFEAASIPLLRRQIVLGTYVVPPGLSEELQDL 251

  Fly   291 IRKFLVLNPTQRTSLSAVMADRWINM---GYEQG-NGLRPFQEKPMDLHDVNRLSLLSNMGHKPR 351
            :...|.:|..||.::..::...|:.:   |:.|. ..|.|.:..|..|.      .:.::|.:.:
  Rat   252 LSLLLKVNSQQRPTIPDLLTHPWLKIDSEGFPQPCKELIPLRPDPAILR------AMQDIGFEAQ 310

  Fly   352 DVEQSLKNQKFDDIYCTYMLLDV------------------------------------AKPR-S 379
            :|:.||..:||:.....|.||:.                                    ::|| .
  Rat   311 EVKDSLDQKKFNQSMACYYLLEKQALQECDNPTRPHPCMTPFPTLDYPATSVRGLRSRGSEPRWL 375

  Fly   380 TACSEKSGSSFRETPT-------AMPGSSRIPVPIAAPNV------TISQVTFAL---------- 421
            .:.|:..||...:||:       :.||.........||.|      :||...|:.
  Rat   376 GSSSDSQGSDLGQTPSHRLVKRASWPGGLLCRPRQIAPTVELTHRISISDPCFSSVHSRGKKTIN 440

  Fly   422 -----DKSTPNRPAATSIRPMAPRLANALTPLPLTPPPKKY-------------ICCSASKAANP 468
                 |||:.    :..::|:|.|           |.||::             :||..     |
  Rat   441 TESTEDKSSD----SAEVKPVASR-----------PWPKRFRGWLKNIRNGLMNLCCCI-----P 485

  Fly   469 RRSEPSSIPQSAMPKK 484
            .|.:|.......:|:|
  Rat   486 SRKKPPLGHNRVVPQK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	104/254 (41%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	104/254 (41%)
Smok2a	NP_001178548.2	STKc_AMPK-like	26..274	CDD:270905	104/254 (41%)
Smok2a	NP_001178548.2	UBA_MARK_Par1	294..333	CDD:270522	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810