DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and SIK3

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001353615.1	Gene:	SIK3 / 23387	HGNCID:	29165	Length:	1369	Species:	Homo sapiens

Alignment Length:	725	Identity:	241/725 - (33%)
Similarity:	335/725 - (46%)	Gaps:	187/725 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SAAAQNVGGCFGSS----------------GGRSSPKFQSYVNGN--------------GYGVYK 64
            :|||...||..|:.                |..::|...|...|.              ..|.|:
Human     3 AAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYE 67

  Fly    65 IIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVI 129
            |.:|:||||||.||.|.||.|..:||||:||||.|:....:|::|||.|||.|.||:|:||.||:
Human    68 IDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM 132

  Fly   130 ESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLD 194
            |:||.:|||.||.||||:|::||.:|||.|::||..|:|:|:|:.:||.::||||||||||||||
Human   133 ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 197

  Fly   195 QQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLP 259
            ..:.:||||||||..|.|...|:|:||||||||||||.||:|.||:||.||||||||.||.|:||
Human   198 ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 262

  Fly   260 FDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGL 324
            |||:.|:.||.|||.||:|:|:::|.|||.|||..|||:|.:|.|:..:...:|:.:|....|..
Human   263 FDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFD 327

  Fly   325 RPF-------QEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLL-DVAK----- 376
            |..       :|:.:|..:.:.|..:.:||.......|||::..:|.....|.|| |..|
Human   328 RLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL 392

  Fly   377 --------PRSTACSEKSGSSFRETPTAMPGSSRIPVP----------IAAPNVTI--------- 414
                    ||:.|..........:..|||    .|.||          |..|:.|:
Human   393 RLGALPSMPRALAFQAPVNIQAEQAGTAM----NISVPQVQLINPENQIVEPDGTLNLDSDEGEE 453

  Fly   415 -----------------------SQVTFALDKSTPNRPAATSIRPMAPRLANA--------LTPL 448
                                   ::|...|.|..|..|   .:.|.||.|..|        |.|:
Human   454 PSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFP---GVNPQAPFLQVAPNVNFMHNLLPM 515

  Fly   449 P---------------LTPPPKKYI-------CCSASKAAN-----------PRRSEPSSIPQSA 480
            .               |.||..:.:       ..::...||           ||...|......|
Human   516 QNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPA 580

  Fly   481 MPKKGVGSPVDVKTT-----LLSAQRKLAVNQK-----LTSASHQIRSPITQSPSQASECTRTPP 535
            :|   ..:|||.:::     ..:.||.||...|     :|:.:.:|...:.:...|....:|..|
Human   581 VP---AVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWP 642

  Fly   536 THFEMLDSTSTPLKVLKLVASNSQTPPSTENT-NRPTRVGFFSKLSARF--VRR------SLHKG 591
            .|               ||....::.....|| :.||.         ||  |||      |:...
Human   643 PH---------------LVPDQHRSTYKDSNTLHLPTE---------RFSPVRRFSDGAASIQAF 683

  Fly   592 EKDISEQGRN 601
            :..:.:.|.|
Human   684 KAHLEKMGNN 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	150/250 (60%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	150/250 (60%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	150/251 (60%)
SIK3	NP_001353615.1	UBA_SIK3	346..390	CDD:270593	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810