Protein Alignment KP78b and SIK3

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001353615.1
• Gene: SIK3 / 23387
• HGNCID: 29165
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 241/725 - (33%)
• Similarity: 335/725 - (46%)
• Gaps: 187/725 - (25%)

  Fly    30 SAAAQNVGGCFGSS----------------GGRSSPKFQSYVNGN--------------GYGVYK 64
            :|||...||..|:.                |..::|...|...|.              ..|.|:
Human     3 AAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYE 67

  Fly    65 IIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVI 129
            |.:|:||||||.||.|.||.|..:||||:||||.|:....:|::|||.|||.|.||:|:||.||:
Human    68 IDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM 132

  Fly   130 ESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLD 194
            |:||.:|||.||.||||:|::||.:|||.|::||..|:|:|:|:.:||.::||||||||||||||
Human   133 ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 197

  Fly   195 QQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLP 259
            ..:.:||||||||..|.|...|:|:||||||||||||.||:|.||:||.||||||||.||.|:||
Human   198 ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 262

  Fly   260 FDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGL 324
            |||:.|:.||.|||.||:|:|:::|.|||.|||..|||:|.:|.|:..:...:|:.:|....|..
Human   263 FDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFD 327

  Fly   325 RPF-------QEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLL-DVAK----- 376
            |..       :|:.:|..:.:.|..:.:||.......|||::..:|.....|.|| |..|
Human   328 RLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL 392

  Fly   377 --------PRSTACSEKSGSSFRETPTAMPGSSRIPVP----------IAAPNVTI--------- 414
                    ||:.|..........:..|||    .|.||          |..|:.|:
Human   393 RLGALPSMPRALAFQAPVNIQAEQAGTAM----NISVPQVQLINPENQIVEPDGTLNLDSDEGEE 453

  Fly   415 -----------------------SQVTFALDKSTPNRPAATSIRPMAPRLANA--------LTPL 448
                                   ::|...|.|..|..|   .:.|.||.|..|        |.|:
Human   454 PSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFP---GVNPQAPFLQVAPNVNFMHNLLPM 515

  Fly   449 P---------------LTPPPKKYI-------CCSASKAAN-----------PRRSEPSSIPQSA 480
            .               |.||..:.:       ..::...||           ||...|......|
Human   516 QNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPA 580

  Fly   481 MPKKGVGSPVDVKTT-----LLSAQRKLAVNQK-----LTSASHQIRSPITQSPSQASECTRTPP 535
            :|   ..:|||.:::     ..:.||.||...|     :|:.:.:|...:.:...|....:|..|
Human   581 VP---AVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWP 642

  Fly   536 THFEMLDSTSTPLKVLKLVASNSQTPPSTENT-NRPTRVGFFSKLSARF--VRR------SLHKG 591
            .|               ||....::.....|| :.||.         ||  |||      |:...
Human   643 PH---------------LVPDQHRSTYKDSNTLHLPTE---------RFSPVRRFSDGAASIQAF 683

  Fly   592 EKDISEQGRN 601
            :..:.:.|.|
Human   684 KAHLEKMGNN 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	150/250 (60%)
		UBA_MARK_Par1	335..373	CDD:270522	10/38 (26%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	150/251 (60%)
		UBA_SIK3	346..390	CDD:270593	12/43 (28%)