DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and gakh-1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_508971.1	Gene:	gakh-1 / 180844	WormBaseID:	WBGene00018516	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	613	Identity:	155/613 - (25%)
Similarity:	258/613 - (42%)	Gaps:	124/613 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QNVGGCFGSSGGRSSPKFQSY-------VNGNGYGVYKIIKTLGKGNFAKVKLAIHLPTGREVAI 91
            |:||     .|...|.:.:.|       :|||.|.|.|:|   .||.|..|.||.: ..|::||:
Worm    11 QSVG-----RGAGISEQSELYDRGQTFSINGNNYRVEKVI---AKGGFGTVFLATN-TKGKQVAV 66

  Fly    92 KLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQV-IESERTLYLVMEYVSGGELFNYLVKNG 155
            |::  .:.:..|.:.:..|:::||||.|.||::|... .||..:...|.||....|...:.:.:.
Worm    67 KIM--LSHDAAATKDIDNEIDMMKKLQHENIIQLFDASAESRSSNRSVKEYKISMEYCKFSIADV 129

  Fly   156 RMRERDARVLFRQLV-----SAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFE-PKA 214
            .::.::..:.|...:     .|:.|.||...:|||:||||||::...|||:.|||.:||.. ..|
Worm   130 LLKYKEVSIDFVVRIIYFTTRALVYLHSVGAIHRDIKAENLLINGNGKLKLCDFGSATTKSIEMA 194

  Fly   215 PL----------ETFCGSPPYA-APELFRGKKYS----GPEVDSWSLGVVLYTLVSGSLPFDGTN 264
            ||          |.|..:.|.. :||:.  ..||    |.:.|:|::|.::|.:..|..||||:.
Worm   195 PLSNSERLAVQEEMFKYTTPITRSPEVC--DVYSNWPIGKQQDNWAMGCLIYFVAFGEHPFDGSA 257

  Fly   265 LKELRDRVLRGKYRVPYYVSIECES----LIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLR 325
            |     .::.|||:.|..|.....|    ||.|.|..||.:|  ::|...:.::.:..::    :
Worm   258 L-----AIINGKYKKPPPVQQNQLSAFADLIAKCLTPNPDER--ITAAKIEEYMKLAMQK----Q 311

  Fly   326 PFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTY--MLLDVAKPRSTACSE--KS 386
            |......|..|:     |..|..:|...|||:::|.....:...  :..::...::|...:  |.
Worm   312 PKLAAKTDFTDI-----LDLMNVQPVQAEQSIESQAAKGFFTMQDKLFSNLTSLKNTVVQQTNKM 371

  Fly   387 GSSFRET-PTAMPGSSRIPVPIAAPNVT--ISQVTFALDKSTPNRPAATSIRPMAPRLANALTPL 448
            |.....| .|..||.     |..:|.:.  ..:.....:|:.|.||..|:    :||.|...|..
Worm   372 GWGMEPTNTTPRPGH-----PSTSPKLVPKTHRSNQQQEKNAPPRPPTTA----SPRAAPVATFK 427

  Fly   449 PLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGVGSPVDVKTT-LLSAQRK---LAVNQKL 509
            ...|...     |.:.:||.......:.|...:.||.|..|.....: .|||:..   |::....
Worm   428 VSWPTDS-----SQNDSANDWGDFSQAPPAVNVSKKDVFDPFSESASHNLSAKHSEDLLSLQNWP 487

  Fly   510 TSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLKVLKLVASNSQTPPSTENTN---RPT 571
            .:|.|:        |...|:.:|      ::.|.....|:         .|.||.|::.   :|.
Worm   488 GTAEHK--------PEVRSQSSR------DLFDFDDLMLR---------HTTPSAESSQAVLQPI 529

  Fly   572 RVGFFSKLSARFVRRSLHKGEKDISEQG 599
            |         :...::|.|  .|:|:.|
Worm   530 R---------QVENKNLTK--VDVSKNG 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	85/276 (31%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	85/276 (31%)
gakh-1	NP_508971.1	PKc_like	38..304	CDD:389743	87/280 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53241
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920