DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and par-1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001122967.2	Gene:	par-1 / 179912	WormBaseID:	WBGene00003916	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	250/537 - (46%)
Similarity:	336/537 - (62%)	Gaps:	38/537 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SGGRSSPKFQSYVNGNG----YGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIA 103
            |.|:|....:|....|.    .|.||::||:|||||||||||.|:.||.|||||:|||||||..:
Worm    82 STGQSGMSSRSAARRNDQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSS 146

  Fly   104 RQKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQ 168
            .|||:|||.|||:|:|||||:|.||:|:|:|||||:||.||||:|:|||.:|||:|::||..|||
Worm   147 LQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQ 211

  Fly   169 LVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRG 233
            :|||::|.|||:|:|||||||||||||.|.:||||||||.||.....|:||||||||||||||.|
Worm   212 IVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSG 276

  Fly   234 KKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLN 298
            |||.|||||.|||||:|||||||||||||.||||||:||||||||:|:|:|.:||:|::||||:|
Worm   277 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVIN 341

  Fly   299 PTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPMDLHD---VNRLSLLSNMGHKPRDVEQSLKNQ 360
            |.:|:||..:|.|||:|:|||. :.|:||.|.|.|..|   :.:|..:..:|.....:.:|::.:
Worm   342 PQRRSSLDNIMKDRWMNVGYED-DELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKE 405

  Fly   361 KFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTAMPGSSRIPVP---IAAPNVTISQVTFALD 422
            ||:||:.||:||...|....|.......|.....:....||....|   |...:||.|..:.:
Worm   406 KFEDIHATYLLLGERKSDMDASEITMAQSLLSHSSINVSSSLGQHPAGVITREHVTSSSASGS-- 468

  Fly   423 KSTPNRPAATSIRPMAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGVG 487
            .::|:|.:.:|.......: .|.:.|......:|:...||:.::....|..||...:|....|
Worm   469 SASPSRYSRSSATATGASI-TAGSALASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAG-- 530

  Fly   488 SPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSP-----SQASECTRTPPTHFEMLDSTSTP 547
                 .|.::|..|...|..:....|.|....:.|.|     |..::..:.||    :.:..||
Worm   531 -----GTVVMSGTRHGGVQMRAQPTSRQATISLLQPPSYKPSSNTTQIAQIPP----LFNRNST- 585

  Fly   548 LKVLKLVASNSQTPPST 564
                   |::|...|||
Worm   586 -------ATSSAAQPST 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	180/250 (72%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	180/250 (72%)
par-1	NP_001122967.2	STKc_MARK	105..357	CDD:270974	180/251 (72%)
		S_TKc	106..357	CDD:214567	180/250 (72%)
		MARK1-3_C	1117..1214	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010