Protein Alignment KP78b and Sik1

DIOPT Version :9

• Sequence 1: NP_001163587.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_034961.2
• Gene: Sik1 / 17691
• MGIID: 104754
• Length: 779
• Species: Mus musculus
• Alignment Length: 561
• Identity: 206/561 - (36%)
• Similarity: 302/561 - (53%)
• Gaps: 88/561 - (15%)

  Fly    50 KFQSYVNGNG--------YGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQK 106
            :|.:..:|.|        .|.|.:.:||||||||.||||.|..|..:||||:||||.|::...:|
Mouse     6 EFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEK 70

  Fly   107 LYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVS 171
            :||||.:||.||||||::|.||:|::..||:|.|:...||:|:||..||.:.|.:||..|.|::|
Mouse    71 IYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILS 135

  Fly   172 AIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKY 236
            |:||||:..|||||||.||||||..|.:|:|||||...::|..||.|:||||||||||:|.||:|
Mouse   136 AVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEY 200

  Fly   237 SGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQ 301
            .||::|.||||||||.||.|||||||.||..||.|||.|::|:|:::|.:||:|||:.||::|.:
Mouse   201 EGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAK 265

  Fly   302 RTSLSAVMADRWINMG---YEQGNGLRPFQEKPMDLHDVNR--LSLLSNMGHKPRDVEQSLKNQK 361
            |.:::.:...||:...   .:|.:.....|....:|.|.|.  |.::..:|...:...:||:|..
Mouse   266 RITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIESLQNSS 330

  Fly   362 FDD---IYCTYMLLDVAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTIS-----QVT 418
            ::.   ||  |:||:               ..:|..:|.|.|...|.|...|.:..|     :|.
Mouse   331 YNHFAAIY--YLLLE---------------RLKEHRSAQPSSRPTPAPTRQPQLRSSDLSSLEVP 378

  Fly   419 FALDKSTPNRPAATSIRPMAPR-----------LANALTPLPLTPPPKKYICCSASKAANPRRSE 472
            ..:....|.||:....:|.|..           |.::|.|| |.|     :..:.|.....|...
Mouse   379 QEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPL-LFP-----LDTNCSGVFRHRSIS 437

  Fly   473 PSSIPQSAMPKKGVGSPVDVKTTLLSAQRKLAVNQKL---TSASHQIRSPITQSPSQASECTRTP 534
            |||:..:|:.::....|        |.:.:..|.:.|   |...|.:        ::.|
Mouse   438 PSSLLDTAISEEARQGP--------SLEEEQEVQEPLPGSTGRRHTL--------AEVS------ 480

  Fly   535 PTHFEMLDSTSTPLKVLKLVASNSQTPPSTENTNRPTRVGF 575
             |||       :||....::.|:|.|...:|.|:..:.:.|
Mouse   481 -THF-------SPLNPPCIIVSSSATASPSEGTSSDSCLPF 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	142/250 (57%)
		S_TKc	63..314	CDD:214567	142/250 (57%)
Sik1	NP_034961.2	STKc_SIK	26..278	CDD:270973	142/251 (57%)
		S_TKc	27..278	CDD:214567	142/250 (57%)
		UBA_SIK1	300..349	CDD:270591	14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..375		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		5/30 (17%)
		RK-rich region	586..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..641

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770