DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and SIK1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_775490.2	Gene:	SIK1 / 150094	HGNCID:	11142	Length:	783	Species:	Homo sapiens

Alignment Length:	613	Identity:	221/613 - (36%)
Similarity:	313/613 - (51%)	Gaps:	111/613 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRL 125
            |.|.|.:||||||||.||||.|..|..:||||:||||.|::...:|:||||.:||.||||:|::|
Human    25 GFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKL 89

  Fly   126 LQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAEN 190
            .||:|::..||:|.|:...||:|:||..||.:.|.:||..|.|::||:||||...|||||||.||
Human    90 YQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTEN 154

  Fly   191 LLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVS 255
            ||||..|.:|:|||||...::...||.|:||||||||||:|.||:|.||::|.||||||||.||.
Human   155 LLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVC 219

  Fly   256 GSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQ 320
            |||||||.||..||.|||.|::|:|:::|.:||||||:.||::|.:|.:::.:...||:.
Human   220 GSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMR----- 279

  Fly   321 GNGLRPFQEKP-------------MDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDD---IYCTY 369
               ..|....|             :..:|...|.::..:|...:...:||:|..::.   ||  |
Human   280 ---AEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIY--Y 339

  Fly   370 MLLDVAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAA--PNVTISQVTFALDKSTPNRPAAT 432
            :||:..|            .:|....|.||.:|.|.|.::  ..:.:.|...:.|   |.|||..
Human   340 LLLERLK------------EYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTD---PFRPALL 389

  Fly   433 SIRP-----------MAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKK-- 484
            ..:|           |...|.::| ..||..|    :..|.|....||...|||:..:|:.::
Human   390 CPQPQTLVQSVLQAEMDCELQSSL-QWPLFFP----VDASCSGVFRPRPVSPSSLLDTAISEEAR 449

  Fly   485 ---GVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTST 546
               |:....|.:.:|.|:..:   ...|...|.:: ||:|......|..|...|......||.
Human   450 QGPGLEEEQDTQESLPSSTGR---RHTLAEVSTRL-SPLTAPCIVVSPSTTASPAEGTSSDSC-- 508

  Fly   547 PLKVLKLVASNSQTP------PSTE---NTNRPTRVG--FFSKLSARFV---------------- 584
                  |..|.|::|      |:|:   ....|.|:.  |....||..|
Human   509 ------LTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVS 567

  Fly   585 ----RR----SLHKGEKDISEQGRNLTK 604
                ||    ||.:|.|...:|.|..|:
Human   568 FQEGRRASDTSLTQGLKAFRQQLRKTTR 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	142/250 (57%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	142/250 (57%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	142/251 (57%)
		S_TKc	27..278	CDD:214567	142/250 (57%)
		UBA_SIK1	300..349	CDD:270591	12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477		5/30 (17%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305\|PubMed:29211348	583..612		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770