DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and Mark2

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006526704.1	Gene:	Mark2 / 13728	MGIID:	99638	Length:	851	Species:	Mus musculus

Alignment Length:	685	Identity:	273/685 - (39%)
Similarity:	384/685 - (56%)	Gaps:	108/685 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TAANTNKTTDKENDPGPNTSISTTATPPSAAAQNVGGCFGSSGGRSSPKFQSYVNGNGYGVYKII 66
            :||.::|.......|    ::....:.||:.:..:.|...::.....|..         |.|:::
Mouse    15 SAAESSKEAAGVTRP----TLGHLDSKPSSKSNMLRGRNSATSADEQPHI---------GNYRLL 66

  Fly    67 KTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIES 131
            ||:|||||||||||.|:.||:|||:|:||||.||:.:.|||:|||.|||.|||||||:|.:|||:
Mouse    67 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIET 131

  Fly   132 ERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQ 196
            |:||||||||.||||:|:|||.:|||:|::||..|||:|||::|||.|.||||||||||||||..
Mouse   132 EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDAD 196

  Fly   197 MKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFD 261
            |.:||||||||..|.....|:||||||||||||||:||||.|||||.|||||:||||||||||||
Mouse   197 MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 261

  Fly   262 GTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRP 326
            |.||||||:||||||||:|:|:|.:||:|::|||:|||::|.:|..:|.|||:|:|:|. :.|:|
Mouse   262 GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED-DELKP 325

  Fly   327 FQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLD-----------VAKPRST 380
            :.|...|..|..|..|:.:||:...:::.||..|:::::..||:||.           ..|||.:
Mouse   326 YVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS 390

  Fly   381 ACSEKSGS-----SFRETPTAMP---GSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPM 437
            |....|.:     ..:.:.:|.|   .||...||....:.:.|:.|.: :.:...||...:.|..
Mouse   391 ADLTNSSAPSPSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQS-NNAENKRPEEETGRKA 454

  Fly   438 APRLANALTPLP------LTPPPKKYICCSASKAANPRRSEP----SSIPQSA---------MPK 483
            :.......:|||      .||.|......|.|  .|..|:.|    :|:.|::         ||
Mouse   455 SSTAKVPASPLPGLDRKKTTPAPSTNSVLSTS--TNRSRNSPLLDRASLGQASIQNGKDSLTMP- 516

  Fly   484 KGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRS---PITQS------PSQASECTRTP---PT 536
             |..:.....:..:||.|.....:.::::.|..::   |.|:|      ||.|.:  |.|   |:
Mouse   517 -GSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQ--RVPVASPS 578

  Fly   537 HFEMLDSTSTPLKV----------------LKLVASNSQTP-------PSTENTNRPTRVG-FFS 577
            ...:..|:..|.:.                |:.|......|       ||..:..|....| .||
Mouse   579 AHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFS 643

  Fly   578 KLSARFVRRSL-------------HKGEKDISEQG 599
            |.:::||||:|             ...|.||..||
Mouse   644 KFTSKFVRRNLSFRFARRCRLSLPKSQELDILRQG 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	177/250 (71%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	177/250 (71%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	177/251 (71%)
		UBA_MARK2	332..373	CDD:270589	13/40 (33%)
		MARK2_C	752..850	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910