Protein Alignment KP78b and sik2a

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001314873.2
• Gene: sik2a / 100126142
• ZFINID: ZDB-GENE-070705-451
• Length: 842
• Species: Danio rerio
• Alignment Length: 531
• Identity: 213/531 - (40%)
• Similarity: 292/531 - (54%)
• Gaps: 76/531 - (14%)

  Fly    61 GVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRL 125
            |.|.|.:||||||||.||||.|..|..|||||:||||.|:.:..:|:||||.|||.|:||:|::|
Zfish    19 GFYDIERTLGKGNFAVVKLARHRITKSEVAIKIIDKTQLDAVNLEKIYREVEIMKLLDHPHIIKL 83

  Fly   126 LQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAEN 190
            .||:|::..||||.||...||:|:||...||:.|.|||..|.|::||:||||.::||||||||||
Zfish    84 YQVMETKNMLYLVTEYARNGEIFDYLASRGRLSEVDARKKFWQILSAVEYCHQRNIVHRDLKAEN 148

  Fly   191 LLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVS 255
            ||||..|.:|||||||...|.|..||.|:||||||||||:|.|::|.||::|.||:|||||.||.
Zfish   149 LLLDTHMNMKIADFGFGNFFRPGEPLTTWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVC 213

  Fly   256 GSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWI------ 314
            |:|||||.:|..||.|||.|::|:||::|.:||.||||.|||:|.:|.|||.:...||:
Zfish   214 GALPFDGPSLPVLRQRVLEGRFRIPYFMSEDCEHLIRKMLVLDPARRLSLSQIKEHRWMVQEVPS 278

  Fly   315 --NMGYEQGNGLRPFQEKP-MDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDD---IYCTYMLLD 373
              .:.|.||   .|.:.|. :..|....|.|:.::|...:...:||:|:.::.   ||  |:|::
Zfish   279 QRPVLYRQG---LPCESKSGLGEHSEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIY--YLLVE 338

  Fly   374 VAKPRSTA--------CSEKSGSSFRETPT----AMPGSSRIPVPIAAPNV--------TISQVT 418
            ..|...::        .|::..|:..|...    |:|..:.:| |.||..:        |....|
Zfish   339 RLKAHRSSFPVEQRLHASQRRPSTVAEQTVVKTIAVPSQAGVP-PQAARQLRSPVLLQSTAETFT 402

  Fly   419 FALDKSTPNRPAATSIRPMAPRLAN------ALTPLPLTPPPKKYICCSASKAANPRRS------ 471
            |      |..||:.....|...:|.      .|.||    ||......|.|..:|...:
Zfish   403 F------PQSPASPDQTLMEEDVATPKVDGCLLDPL----PPVVVRKVSGSLPSNVMETSIDEGI 457

  Fly   472 ---EPSSIPQSAM------PKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQS---- 523
               |..::|.:|.      .::...|.|   |...:||....:|..|:|...|.....|||
Zfish   458 EAEEEHTVPLAAFHTARFSQRRHTLSEV---TNQPAAQPLTDLNPSLSSMDSQYSMGSTQSDCSF 519

  Fly   524 PSQASECTRTP 534
            |.::.....||
Zfish   520 PEESPALNSTP 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	151/250 (60%)
		UBA_MARK_Par1	335..373	CDD:270522	11/40 (28%)
sik2a	NP_001314873.2	None