DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5214 and KGD2

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_010432.3	Gene:	KGD2 / 851726	SGDID:	S000002555	Length:	463	Species:	Saccharomyces cerevisiae

Alignment Length:	395	Identity:	197/395 - (49%)
Similarity:	258/395 - (65%)	Gaps:	7/395 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TSSLWSEQTVNVPPFADSIAEGDIK-FTCKVGDSFAADEAVMEIETDKTTVAVPAPFSGTLTDIL 133
            ||:.:...::.|||.|:|:.||.:| :|..|||....||.:..|||||..:.|.:|.|||:|.:.
Yeast    67 TSNRFKSTSIEVPPMAESLTEGSLKEYTKNVGDFIKEDELLATIETDKIDIEVNSPVSGTVTKLN 131

  Fly   134 VKDGDTVKPGQALFKIKPGAAPAKAAAPAAAPAPAAPKAAPAPAAAPKPAPPPPAAGAPKPPPPP 198
            .|..|||..|:.|.:::||.|||:.:. .:.|.| ..:|.|:...|.:.......|.  |....|
Yeast   132 FKPEDTVTVGEELAQVEPGEAPAEGSG-ESKPEP-TEQAEPSQGVAARENSSEETAS--KKEAAP 192

  Fly   199 PPKAAPRPPPPAPVAALKP--AVAQVKVPPADGSRQILGTRSEQRVKMNRMRLKIAARLKDAQNT 261
            ..:|||:.....|..|.:|  .|::.:.||...:......|:|.|||||||||:||.|||::|||
Yeast   193 KKEAAPKKEVTEPKKADQPKKTVSKAQEPPVASNSFTPFPRTETRVKMNRMRLRIAERLKESQNT 257

  Fly   262 CAMLTTFNEVDMSYAMDFRKQNLDAFTKKYGIKFGFMSIFAKASAYALQDQPVVNAVIDGTDIVY 326
            .|.||||||||||..|:.||...|...||.|.|||||.:|:||...|.:|.|.||..|:|..|||
Yeast   258 AASLTTFNEVDMSALMEMRKLYKDEIIKKTGTKFGFMGLFSKACTLAAKDIPAVNGAIEGDQIVY 322

  Fly   327 RDYVDISVAVATPRGLVVPVIRNVEGMNYADIEIALAGLADKARRDAITVEDMDGGTFTISNGGV 391
            |||.|||||||||:|||.||:||.|.::..|||..:..|:.|||...:|:|||.|||||||||||
Yeast   323 RDYTDISVAVATPKGLVTPVVRNAESLSVLDIENEIVRLSHKARDGKLTLEDMTGGTFTISNGGV 387

  Fly   392 FGSLMGTPIINPPQSAILGMHGIFERPIAVKGEVKIRPMMYIALTYDHRIIDGREAVLFLRKIKA 456
            ||||.||||||.||:|:||:||:.|||:.|.|::..|||||:|||||||::||||||.||:.:|.
Yeast   388 FGSLYGTPIINSPQTAVLGLHGVKERPVTVNGQIVSRPMMYLALTYDHRLLDGREAVTFLKTVKE 452

  Fly   457 AVENP 461
            .:|:|
Yeast   453 LIEDP 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	31/72 (43%)
		sucB	78..468	CDD:273565	195/387 (50%)
		2-oxoacid_dh	255..462	CDD:278621	128/207 (62%)
KGD2	NP_010432.3	sucB	74..463	CDD:273565	195/388 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343971
Domainoid	1	1.000	289	1.000	Domainoid score	I237
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I370
Isobase	1	0.950	-	0	Normalized mean entropy	S583
OMA	1	1.010	-	-		QHG62730
OrthoFinder	1	1.000	-	-		FOG0003446
OrthoInspector	1	1.000	-	-		oto99520
orthoMCL	1	0.900	-	-		OOG6_101182
Panther	1	1.100	-	-	LDO	PTHR43416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R862
SonicParanoid	1	1.000	-	-		X2345
TreeFam	1	0.960	-	-
	15	14.740