Protein Alignment CG5214 and PDHX

DIOPT Version :9

• Sequence 1: NP_650064.1
• Gene: CG5214 / 41360
• FlyBaseID: FBgn0037891
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_003468.2
• Gene: PDHX / 8050
• HGNCID: 21350
• Length: 501
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 131/470 - (27%)
• Similarity: 208/470 - (44%)
• Gaps: 77/470 - (16%)

  Fly    59 TRLLTWQGIHTTSSLWSEQ-TVNVPPFADSIAEGDI-KFTCKVGDSFAADEAVMEIETDKTTVAV 121
            :|...|:..|:|..|..:. .:.:|..:.::.||:| |:..|.|::.:|.:|:.||||||..|.:
Human    38 SRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTL 102

  Fly   122 PAPFSGTLTDILVKDGD-TVKPGQALFKI-------KPGAAPAKAAAPAAAPAPAAPKAAPAPAA 178
            .|...|.|..|:|::|. .::.|..:..|       |....|.....|.....|:.|:.:|.|..
Human   103 DASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQI 167

  Fly   179 A---PKPAPP-------PPAA-------------GAPKPP------------------------- 195
            :   .|...|       .|||             |....|
Human   168 SIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESR 232

  Fly   196 PPPPPKAAPRPPPPAPVAALKPAVAQVKVPPAD--GSRQILGTRSEQRVKMNRMRLKIAARLKDA 258
            |.|.|.|.|..|.|....| .|:..:..:||..  |....:||.:|  :..:.:|..||.||.::
Human   233 PTPAPTATPTAPSPLQATA-GPSYPRPVIPPVSTPGQPNAVGTFTE--IPASNIRRVIAKRLTES 294

  Fly   259 QNTCAMLTTFNEVDMSYAMDFRKQNLDAFTKKYGIKFGFMSIFAKASAYALQDQPVVNAVIDGTD 323
            ::|........:.|:...:..|:..:     |..||........||:|..|:..|.||...||..
Human   295 KSTVPHAYATADCDLGAVLKVRQDLV-----KDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEG 354

  Fly   324 IVYRDYVDISVAVATPRGLVVPVIRNVEGMNYADIEIALAGLADKARRDAITVEDMDGGTFTISN 388
            .....::||||||||.:||:.|:|::.......:|..::..|:.|||...:..|:..||:|:|||
Human   355 PKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISN 419

  Fly   389 GGVFGSLMGTPIINPPQSAILGMHGIFERPIA-----VKGEVKI--RPMMYIALTYDHRIIDGRE 446
            .|:||....|.:|||||:.||.: |.| ||:.     .:|..|:  |.::.:.::.|.|::|...
Human   420 LGMFGIDEFTAVINPPQACILAV-GRF-RPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDEL 482

  Fly   447 AVLFLRKIKAAVENP 461
            |..||:..||.:|||
Human   483 ATRFLKSFKANLENP 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	23/74 (31%)
		sucB	78..468	CDD:273565	126/450 (28%)
		2-oxoacid_dh	255..462	CDD:278621	69/214 (32%)
PDHX	NP_003468.2	PDHac_trf_mito	58..500	CDD:273567	126/450 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..175		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..268		11/43 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810