DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5214 and dbt

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001016963.1	Gene:	dbt / 549717	XenbaseID:	XB-GENE-965456	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	131/517 - (25%)
Similarity:	210/517 - (40%)	Gaps:	95/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MRALRSNEVKRCIRQYSRLV------ACAAQQQQLLRQDGSNR--CQEATRLLTWQGIHTTSSLW 74
            :|||||     |.|...|.|      :|.  |.::||.....:  |:...: :..:.:.||:.|
Frog     4 VRALRS-----CNRSLGRWVGLRQLGSCG--QIRILRSSFPRKTPCRHLQQ-IPHRSLRTTAVL- 59

  Fly    75 SEQTV--NVPPFADSIAEGDIK-FTCKVGDSFAADEAVMEIETDKTTVAVPAPFSGTLTDILVKD 136
            :.|.|  .:....:.|.|..:| :..|.|||.:..:::.|:::||.:|.:.:.:.|.:..:....
Frog    60 NGQIVQFKLSDIGEGITEVTVKDWYVKEGDSVSQFDSICEVQSDKASVTITSRYDGVIRKLHYNV 124

  Fly   137 GDTVKPGQALFKIKPGAAPAKAAAPAAAPAPAAP------------KAAPAPA----AAPKPAPP 185
            .||...|:.|..|:..|....|........||..            |....||    |.......
Frog   125 DDTAYVGKPLVDIETDALKDVAPEEDVVETPAVSHDEHTHQEIKGHKTLATPAVRRLAMENNIKL 189

  Fly   186 PPAAGAPKPPP------------------PPPPKAAPRPPPP---------------APVAALKP 217
            ....|:.|...                  ||.|:....||||               .|...:||
Frog   190 SEVVGSGKDGRILKEDILSFLAKQTGAILPPSPQMEITPPPPKLETSTQQQKAKAASIPAPMIKP 254

  Fly   218 AVAQVK--VPPADGSRQILGTRSEQRVKMNRMRLKIAARLKDAQNTCAMLTTFNEVDMSYAMDFR 280
            .|...|  ..|..|..:.:       ||.....|||     .....|      :||||:.....|
Frog   255 VVFTGKDVTEPLKGFHKAM-------VKTMSAALKI-----PHFGYC------DEVDMTNLSRLR 301

  Fly   281 KQNLDAFTKKYGIKFGFMSIFAKASAYALQDQPVVNAVIDGT--DIVYRDYVDISVAVATPRGLV 343
             ::|....:..|::..||..|.||::..|...|::|:.:|..  :|.|:...:|.:|:.|.:||:
Frog   302 -EDLKPLAESRGVRLSFMPFFLKAASLGLMQFPILNSSVDENCQNITYKAAHNIGIAMDTHQGLI 365

  Fly   344 VPVIRNVEGMNYADIEIALAGLADKARRDAITVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAI 408
            ||.::||:..:..:|...|..|........:...|:.|||||:||.|..|.....|:|.||:.||
Frog   366 VPNVKNVQVRSIFEIAAELNRLQSLGSTGQLGAGDLTGGTFTLSNIGSIGGTYAKPVILPPEVAI 430

  Fly   409 --LGMHGIFERPIAVKGEVKIRPMMYIALTYDHRIIDGREAVLFLRKIKAAVENPAIIVAGL 468
              :|...:..| ...||:|....::.|:.:.|||||||.....|....|:.:|||::::..|
Frog   431 GAIGKVQVLPR-FDSKGQVVKAQIINISWSADHRIIDGATMSRFSNLWKSYLENPSLMLLEL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	18/74 (24%)
		sucB	78..468	CDD:273565	112/447 (25%)
		2-oxoacid_dh	255..462	CDD:278621	64/210 (30%)
dbt	NP_001016963.1	lipoyl_domain	64..137	CDD:133458	17/72 (24%)
		PLN02528	66..492	CDD:215289	112/446 (25%)
		E3_binding	173..206	CDD:280908	5/32 (16%)
		2-oxoacid_dh	277..489	CDD:278621	68/224 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910