DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5214 and CG5599

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	131/496 - (26%)
Similarity:	200/496 - (40%)	Gaps:	106/496 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VKRCIRQYSRLVACAAQQQQLLRQDGSNRCQEATRLLTWQGIHTTSSLWSEQTVNVPPFADSIAE 90
            ::.||.|.:.|..|                           :|.||||....:.|:....:.|.|
  Fly    15 LRNCISQRAALRRC---------------------------LHVTSSLDKTVSFNLSDIGEGIRE 52

  Fly    91 GDIK-FTCKVGDSFAADEAVMEIETDKTTVAVPAPFSGTLTDILVKDGDTVKPGQALFKI----- 149
            ..:| :..|.||:....:.:.|:::||.:|.:.:.:.|.:|.|..|..:....|:.|...
  Fly    53 VTVKEWFVKEGDTVEQFDNLCEVQSDKASVTITSRYDGKITKIHHKIDEIALVGKPLLDFDVVNE 117

  Fly   150 ---KP---GAAPAKAAAPAAAPAPAAPKAAPAPAAAPK-----PAPPP---------------PA 188
               :|   .::.:..::.::|......::|.|.|...:     ||.|.               ||
  Fly   118 DEDEPEDSSSSSSSTSSDSSASENEEKQSAEASATPTEGRVIIPATPSVRRLAKEHQLDLAKVPA 182

  Fly   189 AG----------------APKPPPPPPPKAAPRPPPPAPVAALKPAVAQVKVPPADGSRQILGTR 237
            .|                .|.....|.|....:.|..||..|     |.|.| |||....:.|.|
  Fly   183 TGKNGRVLKGDILEFLGQVPPGTNVPHPTLLAKTPSAAPSGA-----ASVSV-PADRVEVLKGVR 241

  Fly   238 SEQRVKMNRMRLKIAARLKDAQNTCAMLTTFNEVDMSYAMDFRKQNLDAFTKKYGI-KFGFMSIF 301
            ......|.. .|||           ......:|:||:..|.||.| |....|:.|: |..||...
  Fly   242 KAMLKSMTE-SLKI-----------PHFAYSDEIDMTQLMQFRNQ-LQLVAKENGVPKLTFMPFC 293

  Fly   302 AKASAYALQDQPVVNAVID--GTDIVYRDYVDISVAVATPRGLVVPVIRNVEGMNYADIEIALAG 364
            .||::.||...|:||:.:|  ...:|::...:||||:.||:|||||.|:|.:.....:|...|..
  Fly   294 IKAASIALSKYPIVNSSLDLASESLVFKGAHNISVAIDTPQGLVVPNIKNCQTKTIIEIAKDLNA 358

  Fly   365 LADKARRDAITVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGMHGIFERPIAV-----KGE 424
            |.::.|..:::..|...|||::||.||.|.....|.|..||.||    |...|..||     |.|
  Fly   359 LVERGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAI----GAMGRTKAVPRFNDKDE 419

  Fly   425 VKIRPMMYIALTYDHRIIDGREAVLFLRKIKAAVENPAIIV 465
            |....:|.::.:.|||:|||.....|....|..:||||:.:
  Fly   420 VVKAYVMSVSWSADHRVIDGVTMASFSNVWKQYLENPALFL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	17/72 (24%)
		sucB	78..468	CDD:273565	121/444 (27%)
		2-oxoacid_dh	255..462	CDD:278621	72/214 (34%)
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	16/69 (23%)
		PLN02528	41..462	CDD:215289	121/443 (27%)
		E3_binding	161..194	CDD:280908	6/32 (19%)
		2-oxoacid_dh	248..461	CDD:278621	78/230 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740