DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5214 and Dlst

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_006240368.1	Gene:	Dlst / 299201	RGDID:	1359615	Length:	479	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	259/437 - (59%)
Similarity:	312/437 - (71%)	Gaps:	33/437 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GSNRC--QEATRLLTWQGIHTTSSLWSEQ-------------TVNVPPFADSIAEGDIKFTCKVG 100
            |...|  :.|.|.|..:.|: .||::|.:             ||..|.||:|:.|||:::...||
  Rat    57 GPAACPGRSAARFLPSRSIN-NSSVFSVRFFQTTAVCKNDVITVQTPAFAESVTEGDVRWEKAVG 120

  Fly   101 DSFAADEAVMEIETDKTTVAVPAPFSGTLTDILVKDGDTVKPGQALFKI-KPGAAPAKAAAPAAA 164
            |:.|.||.|.|||||||:|.||:|.:|.:..:||.||..|:.|..||.: |.|||||| |.||.|
  Rat   121 DAVAEDEVVCEIETDKTSVQVPSPANGIIEALLVPDGGKVEGGTPLFTLRKTGAAPAK-AKPAEA 184

  Fly   165 PAPAAPKAAP-APAAAPKPAPPPPAAGAPKPPPPPPPKAAPRPPPPAPVAALKPAVAQVKVPPAD 228
            || .|.|||| |||     |||||.|..|...||.|  :..:||...||:|:||..|    ||..
  Rat   185 PA-TAHKAAPEAPA-----APPPPVAPVPTQMPPVP--SPSQPPSSKPVSAIKPTAA----PPLA 237

  Fly   229 GSRQILGTRSEQRVKMNRMRLKIAARLKDAQNTCAMLTTFNEVDMSYAMDFRKQNLDAFTKKYGI 293
            .:....|.|||.|.||||||.:||.|||:|||||||||||||||||...:.|.::.|||.||:.:
  Rat   238 EAGAAKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNL 302

  Fly   294 KFGFMSIFAKASAYALQDQPVVNAVIDGT--DIVYRDYVDISVAVATPRGLVVPVIRNVEGMNYA 356
            |.||||.|.||||:|||:|||||||||..  ::|||||:|||||||||||||||||||||.||||
  Rat   303 KLGFMSAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYA 367

  Fly   357 DIEIALAGLADKARRDAITVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGMHGIFERPIAV 421
            |||..:..|.:|||::.:.:|||||||||||||||||||.|||||||||||||||||||:||:||
  Rat   368 DIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAV 432

  Fly   422 KGEVKIRPMMYIALTYDHRIIDGREAVLFLRKIKAAVENPAIIVAGL 468
            .|:|::|||||:|||||||:|||||||.||||||||||:|.:::..|
  Rat   433 GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	36/84 (43%)
		sucB	78..468	CDD:273565	249/393 (63%)
		2-oxoacid_dh	255..462	CDD:278621	157/208 (75%)
Dlst	XP_006240368.1	sucB	97..479	CDD:273565	249/394 (63%)
		lipoyl_domain	97..169	CDD:133458	36/71 (51%)
		2-oxoacid_dh	264..477	CDD:278621	158/212 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341536
Domainoid	1	1.000	341	1.000	Domainoid score	I1055
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1491
OMA	1	1.010	-	-		QHG62730
OrthoDB	1	1.010	-	-		D422306at33208
OrthoFinder	1	1.000	-	-		FOG0003446
OrthoInspector	1	1.000	-	-		oto96854
orthoMCL	1	0.900	-	-		OOG6_101182
Panther	1	1.100	-	-	LDO	PTHR43416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2345
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770