DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5214 and Dbt

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_445764.1	Gene:	Dbt / 29611	RGDID:	68403	Length:	482	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	119/442 - (26%)
Similarity:	189/442 - (42%)	Gaps:	59/442 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TSSLWSEQTV--NVPPFADSIAEGDIK-FTCKVGDSFAADEAVMEIETDKTTVAVPAPFSGTLTD 131
            |:::...|.|  .:....:.|.|..|| :..|.||:.:..:::.|:::||.:|.:.:.:.|.:..
  Rat    56 TAAVLQGQVVQFKLSDIGEGIREVTIKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKR 120

  Fly   132 ILVKDGDTVKPGQALFKIKPGAAPAKAAAPAAAPAPA----------APKAAPAPA----AAPKP 182
            :.....|....|:.|..|:..|...........||.|          ..|....||    |....
  Rat   121 LYYNLDDIAYVGKPLIDIETEALKDSEEDVVETPAVAHDEHTHQEIKGQKTLATPAVRRLAMENN 185

  Fly   183 APPPPAAGAPKPPP------------------PPPPKAAPRPPPPAPVAALKPAVAQVKVPPADG 229
            .......|:.|...                  ||.||:...||||.|  ..:|....|..||.
  Rat   186 IKLSEVVGSGKDGRILKEDILNFLEKQTGAILPPSPKSEITPPPPQP--RDRPFPTPVSKPPV-- 246

  Fly   230 SRQILG-TRSEQRVKMNRMRLK-IAARLKDAQNTCAMLTTF---NEVDMSYAMDFRKQNLDAFTK 289
               .|| .|:|......:..:| ::|.||        :..|   :|||::..:..|:: |.....
  Rat   247 ---FLGKDRTEPVTGFQKAMVKTMSAALK--------IPHFGYCDEVDLTELVKLREE-LKPVAL 299

  Fly   290 KYGIKFGFMSIFAKASAYALQDQPVVNAVIDGT--DIVYRDYVDISVAVATPRGLVVPVIRNVEG 352
            ..|||..||..|.||::..|...|::||.:|..  .|.|:...:|.:|:.|.|||:||.::||:.
  Rat   300 ARGIKLSFMPFFLKAASLGLLQFPILNASVDENCQSITYKASHNIGIAMDTERGLIVPNVKNVQV 364

  Fly   353 MNYADIEIALAGLADKARRDAITVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGMHGIFER 417
            .:..:|.:.|..|........::..|:.|||||:||.|..|.....|:|.||:.||..:..|...
  Rat   365 RSVFEIAMELNRLQKLGSLGQLSTTDLTGGTFTLSNIGSIGGTYAKPVILPPEVAIGALGAIKAL 429

  Fly   418 P-IAVKGEVKIRPMMYIALTYDHRIIDGREAVLFLRKIKAAVENPAIIVAGL 468
            | ...||:|....:|.::.:.|||:|||.....|....|:.:||||.::..|
  Rat   430 PRFDQKGDVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	17/74 (23%)
		sucB	78..468	CDD:273565	116/432 (27%)
		2-oxoacid_dh	255..462	CDD:278621	68/212 (32%)
Dbt	NP_445764.1	lipoyl_domain	65..138	CDD:133458	16/72 (22%)
		PLN02528	67..482	CDD:215289	116/431 (27%)
		E3_binding	172..205	CDD:280908	5/32 (16%)
		2-oxoacid_dh	267..479	CDD:278621	71/220 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810