DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5214 and DLAT

DIOPT Version :9

Sequence 1:	NP_650064.1	Gene:	CG5214 / 41360	FlyBaseID:	FBgn0037891	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001358960.1	Gene:	DLAT / 1737	HGNCID:	2896	Length:	653	Species:	Homo sapiens

Alignment Length:	437	Identity:	127/437 - (29%)
Similarity:	181/437 - (41%)	Gaps:	47/437 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SSLWSEQTVNVPPFADSIAEGDI-KFTCKVGDSFAADEAVMEIETDKTTVAVPAPFSGTLTDILV 134
            ||......|.:|..:.::..|.: ::..|||:..:..:.:.||||||.|:.......|.|..|||
Human   213 SSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILV 277

  Fly   135 KDGDTVKP-GQALFKIKPGAAPAKAAA---PAAAP--APAAPKAAPAPAAAPKPAPPP--PAAGA 191
            .:|....| |..|..|....|...|.|   |....  .|..|...|.|.||..|.|.|  |...|
Human   278 PEGTRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSA 342

  Fly   192 PKPPPPPPPKAAPRPPPPAPVAALKPAV--AQVK----------------------------VPP 226
            |.|..|..||......|.|...|::..:  .|||                            |||
Human   343 PCPATPAGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPP 407

  Fly   227 ADGSRQILGTRSEQRVKMNRMRLKIAARLKDAQNTCAMLTTFNEVDMSYAMDFRKQNLDAFTKKY 291
            .......:.|.....:.::.:|..||.||..::.|........:|:|...:..||: |:.|...:
Human   408 TGPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKE-LNKFFLSF 471

  Fly   292 GI-----KFGFMSIFAKASAYALQDQPVVNAVIDGTDIVYRDYVDISVAVATPRGLVVPVIRNVE 351
            .|     |........||||.|....|..|:....|.|.....||:||||:||.||:.|::.|..
Human   472 QILEGRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAH 536

  Fly   352 GMNYADIEIALAGLADKARRDAITVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGMHGIFE 416
            ......|...:..||.|||...:...:..||||||||.|:||....:.||||||:.||.:....:
Human   537 IKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASED 601

  Fly   417 RPIAVKGE--VKIRPMMYIALTYDHRIIDGREAVLFLRKIKAAVENP 461
            :.:....|  ..:..||.:.|:.|||::||.....:|.:.:..:|.|
Human   602 KLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5214	NP_650064.1	lipoyl_domain	77..149	CDD:133458	22/73 (30%)
		sucB	78..468	CDD:273565	125/430 (29%)
		2-oxoacid_dh	255..462	CDD:278621	68/214 (32%)
DLAT	NP_001358960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..49
		PRK11892	96..>175	CDD:237011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		2/5 (40%)
		PDHac_trf_mito	221..653	CDD:273567	125/429 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..346		12/33 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810