DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31388 and ZNF8

DIOPT Version :9

Sequence 1:NP_650060.1 Gene:CG31388 / 41355 FlyBaseID:FBgn0051388 Length:446 Species:Drosophila melanogaster
Sequence 2:NP_066575.2 Gene:ZNF8 / 7554 HGNCID:13154 Length:575 Species:Homo sapiens


Alignment Length:361 Identity:89/361 - (24%)
Similarity:135/361 - (37%) Gaps:83/361 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 ASPQSSPELST-------DSQLSNEHFDMGL------SPESEPESEAIDNRDTSSS--------- 194
            :||...||:|.       |||:::...:..|      ||..:|...:..:||:|.:         
Human   186 SSPNPFPEISRGEYLYTYDSQITDSEHNSSLVSQQTGSPGKQPGENSDCHRDSSQAIPITELTKS 250

  Fly   195 ------HTCSKCGLEFENVDELKLHK-YHLHDIPPDTKFVCDHCDEGFRSAAALTRHCNMINLPL 252
                  :.|:.||..|.:...|.:|| .|..:.|    ::|..|.:.|...::|.:|..:.....
Human   251 QVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERP----YMCKECGKAFSQNSSLVQHERIHTGDK 311

  Fly   253 THSCTKCKSQFHNHILLETHKQRCLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKCDQC 317
            .:.|.:|...|.:...|..|::  :......:.|..||:......:|..|...|.|.:.:.|..|
Human   312 PYKCAECGKSFCHSTHLTVHRR--IHTGEKPYECQDCGRAFNQNSSLGRHKRTHTGEKPYTCSVC 374

  Fly   318 SASFYTAAELCSHQKTHTTERPYICRYNCGKTFRFCSARSMHERVH------------------- 363
            ..||.....|..|.:|||.||||.|.: |||.||..|:.:.|:|.|                   
Human   375 GKSFSRTTCLFLHLRTHTEERPYECNH-CGKGFRHSSSLAQHQRKHAGEKPFECRQRLIFEQTPA 438

  Fly   364 ---------------------MDASKRIYQCEYCPKSYVTPSECRTHQKYHNLTRD---HGCEIC 404
                                 ...|.|.::|..|.|.::..|....||..|  ||:   ||....
Human   439 LTKHEWTEALGCDPPLSQDERTHRSDRPFKCNQCGKCFIQSSHLIRHQITH--TREEQPHGRSRR 501

  Fly   405 R-ISFKTAKHYRSHLKSNAHKTLEARAKAAASPNSR 439
            | .|.....|...|...|:.|:....|| |..|.||
Human   502 REQSSSRNSHLVQHQHPNSRKSSAGGAK-AGQPESR 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31388NP_650060.1 zf-AD 4..76 CDD:285071
C2H2 Zn finger 228..254 CDD:275368 5/25 (20%)
C2H2 Zn finger 286..306 CDD:275368 5/19 (26%)
C2H2 Zn finger 314..334 CDD:275368 6/19 (32%)
C2H2 Zn finger 342..363 CDD:275368 9/20 (45%)
C2H2 Zn finger 373..393 CDD:275368 6/19 (32%)
C2H2 Zn finger 401..419 CDD:275368 4/18 (22%)
ZNF8NP_066575.2 KRAB 25..85 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..130
COG5048 <167..404 CDD:227381 56/224 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..237 4/26 (15%)
C2H2 Zn finger 259..279 CDD:275368 7/19 (37%)
C2H2 Zn finger 287..307 CDD:275368 5/19 (26%)
C2H2 Zn finger 315..335 CDD:275368 5/21 (24%)
C2H2 Zn finger 343..363 CDD:275368 5/19 (26%)
C2H2 Zn finger 371..391 CDD:275368 6/19 (32%)
zf-C2H2 397..419 CDD:306579 10/22 (45%)
C2H2 Zn finger 399..419 CDD:275368 9/20 (45%)
zf-C2H2 467..489 CDD:306579 6/21 (29%)
C2H2 Zn finger 469..489 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..533 14/47 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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