Protein Alignment CG31388 and SNAI1

DIOPT Version :9

• Sequence 1: NP_650060.1
• Gene: CG31388 / 41355
• FlyBaseID: FBgn0051388
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_005976.2
• Gene: SNAI1 / 6615
• HGNCID: 11128
• Length: 264
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 68/298 - (22%)
• Similarity: 111/298 - (37%)
• Gaps: 66/298 - (22%)

  Fly   101 PDELSNLSPVLQLNDRMDFIFDPEPQDKNTDELASIK-----TTTTTEYMNAYQSVASPQS---- 156
            |:...|.|.:...|....|   .:|.|: ...||:|.     ..|.:..|..:.||.:||:
Human    13 PNRKPNYSELQDSNPEFTF---QQPYDQ-AHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIA 73

  Fly   157 --------SPELSTDSQLSNEHFDMGLSPESEPESEAIDNRDTSSSHTCSKCGLEFENVDELKLH 213
                    ||.::..:.||:|....|..|.|.|.........||.|...::....|..:.::...
Human    74 WASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQ 138

  Fly   214 KYHL---HDIPPDTKFVCDHCDEGFRSAAALTRHCNMINLPLTHSCTKCKSQFHNHILLETHKQR 275
            ...|   .|:.....|.|.:|::.:.|..||..|                        :.:|...
Human   139 LAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMH------------------------IRSHTLP 179

  Fly   276 CLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKCDQCSASFYTAAELCSHQKTHTTERPY 340
            |        ||..|||..:..:.|:.|:..|.|.:...|..||.:|...:.|.:|.:||:..:.|
Human   180 C--------VCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKY 236

  Fly   341 ICRYNCGKTFRFCSARSMHERVHMDASKRIYQCEYCPK 378
            .|: .|.:||...|.  :|:  |.::.     |..||:
Human   237 QCQ-ACARTFSRMSL--LHK--HQESG-----CSGCPR 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071
		C2H2 Zn finger	228..254	CDD:275368	6/25 (24%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..363	CDD:275368	6/20 (30%)
		C2H2 Zn finger	373..393	CDD:275368	3/6 (50%)
		C2H2 Zn finger	401..419	CDD:275368
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		3/13 (23%)
		SNAG domain. /evidence=ECO:0000305|PubMed:20389281, ECO:0000305|PubMed:21300290	1..20		2/6 (33%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:23721412	2..7
		LATS2 binding	10..40		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..115		7/28 (25%)
		Destruction motif	95..100		0/4 (0%)
		Required for FBXL14-triggered degradation	120..151		3/30 (10%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269|PubMed:21577210, ECO:0000269|PubMed:22128911	151..264		36/154 (23%)
		C2H2 Zn finger	156..176	CDD:275368	6/43 (14%)
		C2H2 Zn finger	182..202	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..218	CDD:404364	7/22 (32%)
		zf-C2H2	208..230	CDD:395048	6/21 (29%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	238..255	CDD:275368	6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100