DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31388 and ZNF692

DIOPT Version :9

Sequence 1:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_011542525.1	Gene:	ZNF692 / 55657	HGNCID:	26049	Length:	625	Species:	Homo sapiens

Alignment Length:	354	Identity:	86/354 - (24%)
Similarity:	133/354 - (37%)	Gaps:	97/354 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RRVCIEA---QELLELQLRQVEKEEEAFESLAEQWLDDCPDELSNLSPVLQLNDRMDFIFDPEPQ 126
            |..|.||   |||.:|:....|:.:||....:|   .|.|..|.  |||           ...|:
Human   296 RSWCSEATSGQELADLESEHDERTQEARLPSSE---PDAPRLLP--SPV-----------TCTPK 344

  Fly   127 DKNTDELASIKTTTTTEYMNAYQSVASPQSSPELSTDS---------------QLSNEHFDMGLS 176
            :..|..              |..:::||.:.|.||..|               |||.       :
Human   345 EGETPP--------------APAALSSPLAVPALSASSLSSRAPPPAEVRVQPQLSR-------T 388

  Fly   177 PESEPESEAIDNRDTSSSHTCSKCGLEFENVDEL---KLHKYHLHDIPPDTKFVCDH--CDEGFR 236
            |::..::||:  ..|.|....:......|:..::   ::.|....::.|     ||.  |...|.
Human   389 PQAAQQTEAL--ASTGSQAQSAPTPAWDEDTAQIGPKRIRKAAKRELMP-----CDFPGCGRIFS 446

  Fly   237 SAAALTRHCNMINLPLTHSCTKCKSQFHNHILLETHKQRCLRPPASQHVCHICGKHLTTAFNLKN 301
            :...|..|               |...|.|     .|......||       |||......:||.
Human   447 NRQYLNHH---------------KKYQHIH-----QKSFSCPEPA-------CGKSFNFKKHLKE 484

  Fly   302 HLVRHAGTRRHKCDQCSASFYTAAELCSHQKTHTTERPYICRYNCGKTFRFCSARSMHERVHMDA 366
            |:..|:.||.:.|:.|:.||.|::.|..|::.||.|:|..|.. ||.|.|..::.:.|:|.|.:.
Human   485 HMKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEI-CGFTCRQKASLNWHQRKHAET 548

  Fly   367 SKRI-YQCEYCPKSYVTPSECRTHQ-KYH 393
            ...: :.||:|.|.:..|.....|: |.|
Human   549 VAALRFPCEFCGKRFEKPDSVAAHRSKSH 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071	7/13 (54%)
		C2H2 Zn finger	228..254	CDD:275368	6/27 (22%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..363	CDD:275368	7/20 (35%)
		C2H2 Zn finger	373..393	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..419	CDD:275368
ZNF692	XP_011542525.1	zf-C2H2	465..489	CDD:278523	8/30 (27%)
		C2H2 Zn finger	467..489	CDD:275368	8/28 (29%)
		COG5048	490..>591	CDD:227381	29/89 (33%)
		zf-C2H2	495..517	CDD:278523	7/21 (33%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..534	CDD:290200	10/25 (40%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		C2H2 Zn finger	556..577	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100