DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31388 and ZNF581

DIOPT Version :9

Sequence 1:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_057619.1	Gene:	ZNF581 / 51545	HGNCID:	25017	Length:	197	Species:	Homo sapiens

Alignment Length:	249	Identity:	52/249 - (20%)
Similarity:	79/249 - (31%)	Gaps:	98/249 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SVASPQ-SSPE-----LSTDSQLSNEHFDMGLSPESEPESEAIDNRDTSSSHTCSKCGLEFENVD 208
            |:.||| |||.     |..|:|  ...:.:.:..||:.|..|.........::|..|...||.:.
Human    38 SIGSPQASSPPRPNHYLLIDTQ--GVPYTVLVDEESQREPGASGAPGQKKCYSCPVCSRVFEYMS 100

  Fly   209 ELKLHKYHLHDIPPDTKFVCDHCDEGFRSAAALTRHCNMINLPLTHSCTKCKSQFHNHILLETHK 273
            .|:.|.....::.|   |.||.|.:.|:.|:.|.||
Human   101 YLQRHSITHSEVKP---FECDICGKAFKRASHLARH----------------------------- 133

  Fly   274 QRCLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKCDQCSASFYTAAELCSHQKTHTTER 338
                      |..|:.|                 |.|.|.|..|...|..|.||..|.:.|:.||
Human   134 ----------HSIHLAG-----------------GGRPHGCPLCPRRFRDAGELAQHSRVHSGER 171

  Fly   339 PYICRYNCGKTFRFCSARSMHERVHMDASKRIYQCEYCPKSYVTPSECRTHQKY 392
            |                               :||.:||:.::..:..:.|.::
Human   172 P-------------------------------FQCPHCPRRFMEQNTLQKHTRW 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071
		C2H2 Zn finger	228..254	CDD:275368	8/25 (32%)
		C2H2 Zn finger	286..306	CDD:275368	2/19 (11%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..363	CDD:275368	0/20 (0%)
		C2H2 Zn finger	373..393	CDD:275368	4/20 (20%)
		C2H2 Zn finger	401..419	CDD:275368
ZNF581	NP_057619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		7/13 (54%)
		C2H2 Zn finger	89..109	CDD:275368	6/19 (32%)
		zf-H2C2_2	101..126	CDD:404364	8/27 (30%)
		C2H2 Zn finger	117..137	CDD:275368	9/58 (16%)
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		C2H2 Zn finger	175..193	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100