DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31388 and Zfp707

DIOPT Version :9

Sequence 1:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001129369.1	Gene:	Zfp707 / 315088	RGDID:	1311188	Length:	390	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	93/363 - (25%)
Similarity:	141/363 - (38%)	Gaps:	42/363 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QIAIDFRRV----CIEAQELLELQLRQVEKEE--EAFESLAEQWLDDCPDELSNLSPVLQLNDRM 117
            |:.:.||.|    |.|..|.|....|.:.::.  |.|.:|.|  |..|..:.|.:|.:.|.::..
  Rat    37 QVPVTFREVAVYFCREEWECLSFSQRTLYRDVMLENFRNLNE--LGCCGRKPSLISRLEQWDEPW 99

  Fly   118 DFIFDPEPQDKNTDELASIKTTTTTEYMNAYQSVASPQSSPELSTDSQLSNE-HFDMGLSPES-E 180
            ...:|....::........:..:..|..:   |....:|...|..:...|.: ||....|... :
  Rat   100 VDKWDSSELERQKSVCPGGRKASAPEKTH---SRTGAKSRTTLRKNVLTSGKAHFTRATSGRKLD 161

  Fly   181 PESEAIDNRDTSSSH-------------------TCSKCGLEFENVDELKLHKYHLHDIPPDTK- 225
            .:|||:.|:....|.                   .|..||........|..|:    .:...|:
  Rat   162 NKSEALQNQTCGKSRRRQPGLKEQGKSAAEGHPFICGICGKALSCHSRLAAHQ----TVHTGTRS 222

  Fly   226 FVCDHCDEGFRSAAALTRHCNMINLPLTHSCTKCKSQFHNHILLETHKQRCLRPPASQHVCHICG 290
            |.|..|.:.||..:.|.||...........|..|...|.....|..|::  :......:||..||
  Rat   223 FECFECGQTFRWVSNLLRHQRNHTSEKPFCCEVCGQAFSLKDRLAQHQK--IHTEHRPYVCSDCG 285

  Fly   291 KHLTTAFNLKNHLVRHAGTRRHKCDQCSASFYTAAELCSHQKTHTTERPYICRYNCGKTFRFCSA 355
            |......||..|.:.|.|.|...||.|..:|.|...|..||:.|:.|:||.|. .|||.||:...
  Rat   286 KAFKQKSNLLRHKLVHTGERPFYCDNCGKTFRTKENLNHHQRIHSGEKPYTCG-ECGKAFRWPKG 349

  Fly   356 RSMHERVHMDASKRIYQCEYCPKSYVTPSECRTHQKYH 393
            .|:|:|:|:  :|:.|:||.|.|.:........||:.|
  Rat   350 FSIHQRLHL--TKKFYECEECGKGFRHLGFFTRHQRTH 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071	7/20 (35%)
		C2H2 Zn finger	228..254	CDD:275368	7/25 (28%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		C2H2 Zn finger	342..363	CDD:275368	9/20 (45%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..419	CDD:275368
Zfp707	NP_001129369.1	KRAB	40..100	CDD:214630	17/61 (28%)
		KRAB	40..76	CDD:279668	10/35 (29%)
		C2H2 Zn finger	197..217	CDD:275368	5/23 (22%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		zf-H2C2_2	237..261	CDD:290200	5/23 (22%)
		COG5048	<249..385	CDD:227381	46/140 (33%)
		C2H2 Zn finger	253..273	CDD:275368	5/21 (24%)
		zf-H2C2_2	266..290	CDD:290200	7/25 (28%)
		zf-C2H2	279..301	CDD:278523	8/21 (38%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..318	CDD:290200	10/24 (42%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		zf-H2C2_2	321..344	CDD:290200	11/23 (48%)
		C2H2 Zn finger	337..357	CDD:275368	9/20 (45%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100