DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31388 and ZNF660

DIOPT Version :9

Sequence 1:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_775929.2	Gene:	ZNF660 / 285349	HGNCID:	26720	Length:	331	Species:	Homo sapiens

Alignment Length:	238	Identity:	65/238 - (27%)
Similarity:	108/238 - (45%)	Gaps:	14/238 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 HTCSKCGLEFENVDELKLHKYHLHDIPPDTKFVCDHCDEGFRSAAALTRHCNMINLPLTHSCTKC 259
            :.|.:||..|.:...|.:|:.....:.|   :.|..|.:.|...:.|.||..:.:...|:.|.:|
Human    78 YKCKECGKAFSHSSNLVVHRRIHTGLKP---YTCSECGKSFSGKSHLIRHQGIHSGEKTYECKEC 139

  Fly   260 KSQF-HNHILLETHKQRCLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKCDQCSASFYT 323
            ...| .:..|:..|:......|.|   |..|||..:.:.||..|...|.|.:.:||.:|..:..:
Human   140 GKAFSRSSGLISHHRVHTGEKPYS---CIECGKAFSRSSNLTQHQRMHRGKKVYKCKECGKTCGS 201

  Fly   324 AAELCSHQKTHTTERPYICRYNCGKTFRFCSARSMHERVHMDASKRIYQCEYCPKSYVTPSECRT 388
            ..::..||:.||.|:||.|. .|||||......:.|:|:|  ..::.|:|..|.|::.:......
Human   202 NTKIMDHQRIHTGEKPYECD-ECGKTFILRKTLNEHQRLH--RREKPYKCNECGKAFTSNRNLVD 263

  Fly   389 HQKYHNLTRDHGCEICRISFKTAK----HYRSHLKSNAHKTLE 427
            ||:.|...:.:.|..|..:|:...    |.|:|.|...:|..|
Human   264 HQRVHTGEKPYKCNECGKTFRQTSQVILHLRTHTKEKPYKCSE 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071
		C2H2 Zn finger	228..254	CDD:275368	6/25 (24%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		C2H2 Zn finger	342..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..419	CDD:275368	6/21 (29%)
ZNF660	NP_775929.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C2H2 Zn finger	52..72	CDD:275368
		zf-H2C2_2	64..89	CDD:316026	4/10 (40%)
		C2H2 Zn finger	80..100	CDD:275368	6/19 (32%)
		COG5048	<107..294	CDD:227381	53/192 (28%)
		C2H2 Zn finger	108..128	CDD:275368	6/19 (32%)
		C2H2 Zn finger	136..156	CDD:275368	5/19 (26%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		C2H2 Zn finger	192..207	CDD:275368	2/14 (14%)
		C2H2 Zn finger	220..240	CDD:275368	8/20 (40%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		C2H2 Zn finger	304..324	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100