DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31388 and bcl-11

DIOPT Version :9

Sequence 1:	NP_650060.1	Gene:	CG31388 / 41355	FlyBaseID:	FBgn0051388	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001122913.1	Gene:	bcl-11 / 179019	WormBaseID:	WBGene00017430	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	370	Identity:	71/370 - (19%)
Similarity:	121/370 - (32%)	Gaps:	100/370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PAVAKNLFDPSSSSVLRQIETLTNLQ-LKEDGKLPRFMCQDCQHDLQIAIDFRRVCIEAQELLEL 77
            |.:|.....||..:...|:...|:.. |......|:..........|.:.....|.::...|..:
Worm   299 PLMALRRLMPSEETEEEQVSAFTSTSLLNSRASQPQLPTVSSSAGFQTSGSMPNVWMQPSMLAAM 363

  Fly    78 QLRQVEKEEEAFESLAEQWLDDCPDELSNLSPVLQLNDRMDFIFDPEPQDKNTDELASIKTTTTT 142
            |        |.:.|:.:.     |..::|.:.|..||...:.....:.|.:...:..::
Worm   364 Q--------EYYASIQQM-----PYPMTNSTAVALLNISNNLQQQQQQQQQLQQQQQNL------ 409

  Fly   143 EYMNAYQSVASPQ---SSPELSTDSQLSNEHFDMGLSPESEPESEAIDNRDTSSSH-TCSKCGLE 203
              :.|...||:||   .:|...:.::||... :...:|  .|.|.||..|.:.... |..:..::
Worm   410 --IAAQPQVATPQPPAPTPLFQSLNRLSTAD-ESSYTP--RPASVAIRRRASPEEELTPPRKSMK 469

  Fly   204 FENVDELKLHKYHLHDIPPDTKFVCDHCDEGFRSAAALTRHCNMINLPLTHSCTKCKSQFHNHIL 268
            .|..|:|.:                  .|:|..:..|..:..|:
Worm   470 IEEEDQLIV------------------VDDGELAEPAARKPNNI--------------------- 495

  Fly   269 LETHKQRCLRPPASQHVCHICGKHLTTAFNLKNHLVRHAGTRRHKCDQCSASFYTAAELCSHQKT 333
               .|:|          |:.|.|..|...||..||..|.|.:.:||..|..:...:::|..|.:|
Worm   496 ---KKER----------CNFCNKVFTNRSNLIVHLRSHTGEKPYKCQLCPYACAQSSKLTRHMRT 547

  Fly   334 H-----TTERPYICRYNCGKTFRFCSARSMHERVHMDASKRIYQC 373
            |     .|...||||              |...||....|.:.:|
Worm   548 HGQQGKETYHCYICR--------------MPFSVHSTLEKHMRKC 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31388	NP_650060.1	zf-AD	4..76	CDD:285071	11/62 (18%)
		C2H2 Zn finger	228..254	CDD:275368	4/25 (16%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		C2H2 Zn finger	342..363	CDD:275368	3/20 (15%)
		C2H2 Zn finger	373..393	CDD:275368	1/1 (100%)
		C2H2 Zn finger	401..419	CDD:275368
bcl-11	NP_001122913.1	zf-C2H2	499..520	CDD:278523	9/30 (30%)
		zf-C2H2_2	500..>577	CDD:289522	26/90 (29%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		zf-H2C2_2	512..537	CDD:290200	9/24 (38%)
		C2H2 Zn finger	528..548	CDD:275368	4/19 (21%)
		C2H2 Zn finger	558..576	CDD:275368	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100