DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arfip and Arfip2

DIOPT Version :9

Sequence 1:	NP_650058.1	Gene:	Arfip / 41353	FlyBaseID:	FBgn0037884	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_084078.3	Gene:	Arfip2 / 76932	MGIID:	1924182	Length:	341	Species:	Mus musculus

Alignment Length:	355	Identity:	163/355 - (45%)
Similarity:	224/355 - (63%)	Gaps:	50/355 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERSIHEMLKDAPSLNDSCGAVHTGTEGGSGILGSASSHSIAGGGGGGGNVGVGVGGPFGAPSSLP 69
            |:.:.:::...|:||::                     ||..||.||...|:           :|
Mouse    32 EQDLQQVMVSGPNLNET---------------------SIVSGGYGGSGDGL-----------IP 64

  Fly    70 LRNHSAPTTPMSPSSPPS--GNGILSPTDSGSGSIIRTSASKIDSLKNWSISTYKCTRQIMLEKL 132
            ..:...|:...|||.|..  ..||              :..|.|.:|.|.|:|||||:|::.|:.
Mouse    65 TGSGRHPSHSTSPSGPGDEVARGI--------------AGEKFDIVKKWGINTYKCTKQLLSERF 115

  Fly   133 GKSQRTVDSELEAQIEQLRETQRKYLSILRLTRAFSSHFQHVVVTQHALADSFADLAQKNPELQK 197
            |:..||||.|||.|||.||||:|||.|:|:|.||.::|...::.|||||.|:||||:||:||||:
Mouse   116 GRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQE 180

  Fly   198 EFTCNSETQRNLTKNGELLLNALNFFISSVNTLCNKTIDDTLLTIRQYETARIEFDAYRMDLENT 262
            ||..|:|||:.|.||||.||.|:|||:||:|||..||::|||:|::|||.||:|:||||.|||..
Mouse   181 EFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEEL 245

  Fly   263 K--PELTPSAVALEETQRSYAQHKEQYEKLRSDVAVKMQFLDENRIKVMHKQLILLHNAIAAYFS 325
            .  |....:...||..|.::..|:::|||||.|||:|::||:||:||||||||:|.|||::|||:
Mouse   246 SLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFA 310

  Fly   326 GNAMALESTLKQFNIKLKSPNAVTGSWLEQ 355
            ||...||.||:||||||:.|.|...||||:
Mouse   311 GNQKQLEQTLQQFNIKLRPPGAEKPSWLEE 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arfip	NP_650058.1	BAR_Arfaptin	140..338	CDD:153344	116/199 (58%)
Arfip2	NP_084078.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..84		14/69 (20%)
Arfip2	NP_084078.3	BAR_Arfaptin	136..323	CDD:153344	106/186 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831571
Domainoid	1	1.000	267	1.000	Domainoid score	I1858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8234
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2614
Isobase	1	0.950	-	0	Normalized mean entropy	S3987
OMA	1	1.010	-	-		QHG48818
OrthoDB	1	1.010	-	-		D1179170at2759
OrthoFinder	1	1.000	-	-		FOG0003325
OrthoInspector	1	1.000	-	-		otm44107
orthoMCL	1	0.900	-	-		OOG6_105484
Panther	1	1.100	-	-	LDO	PTHR12141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5434
SonicParanoid	1	1.000	-	-		X2693
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890