DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arfip and ARFIP1

DIOPT Version :9

Sequence 1:	NP_650058.1	Gene:	Arfip / 41353	FlyBaseID:	FBgn0037884	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_011530170.1	Gene:	ARFIP1 / 27236	HGNCID:	21496	Length:	379	Species:	Homo sapiens

Alignment Length:	338	Identity:	158/338 - (46%)
Similarity:	223/338 - (65%)	Gaps:	24/338 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HSIAGGGG---------GGGNVGVGV--GGPFGAPSSLPLRNHSAPTTPMSPSSPPSGNGILSP- 94
            ||:..|.|         |..|...||  .|.|....:.||.:..:|:...:......|:.::.|
Human    41 HSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPA 105

  Fly    95 ----TDSGSGSII------RTSASKIDSLKNWSISTYKCTRQIMLEKLGKSQRTVDSELEAQIEQ 149
                |.:.||.:|      ..:..|::.::.||::||||||||:.||||:..||||.||||||:.
Human   106 GGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDI 170

  Fly   150 LRETQRKYLSILRLTRAFSSHFQHVVVTQHALADSFADLAQKNPELQKEFTCNSETQRNLTKNGE 214
            ||:.::||.:||:|.:..|:....:|.||..|.|:||||:.|:.||.:||..|::||:.|.||||
Human   171 LRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGE 235

  Fly   215 LLLNALNFFISSVNTLCNKTIDDTLLTIRQYETARIEFDAYRMDLE--NTKPELTPSAVALEETQ 277
            .||.|:||||:|||||.||||:|||:|::|||:||||:||||.|||  |..|....:...:|::|
Human   236 TLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQ 300

  Fly   278 RSYAQHKEQYEKLRSDVAVKMQFLDENRIKVMHKQLILLHNAIAAYFSGNAMALESTLKQFNIKL 342
            ..:..|||:|:|:|:||:||::||:||::||:|.||:|.||||||||:||...||.|||||:|||
Human   301 HLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKL 365

  Fly   343 KSPNAVTGSWLEQ 355
            |:|.....||||:
Human   366 KTPGVDAPSWLEE 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arfip	NP_650058.1	BAR_Arfaptin	140..338	CDD:153344	110/199 (55%)
ARFIP1	XP_011530170.1	BAR_Arfaptin	161..361	CDD:153344	110/199 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141624
Domainoid	1	1.000	267	1.000	Domainoid score	I1881
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2648
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1179170at2759
OrthoFinder	1	1.000	-	-		FOG0003325
OrthoInspector	1	1.000	-	-		otm42052
orthoMCL	1	0.900	-	-		OOG6_105484
Panther	1	1.100	-	-	O	PTHR12141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5434
SonicParanoid	1	1.000	-	-		X2693
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930