DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6689 and ZNF585B

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_689492.3	Gene:	ZNF585B / 92285	HGNCID:	30948	Length:	769	Species:	Homo sapiens

Alignment Length:	550	Identity:	131/550 - (23%)
Similarity:	200/550 - (36%)	Gaps:	158/550 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 EEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLE--ELQKCRTCYNDFTADFRAKDLFDPA 187
            :..|:|..:..|.:...:|            |||:..|  |..|..|..:.|....:.     |.
Human   106 QHRKIIGYKPASSQDQKIY------------SGEKSYECAEFGKSFTWKSQFKVHLKV-----PT 153

  Fly   188 NSVLLFHIE-----VISGVWISHKPDEPR---LMCPAC-KSALDQAIDFREMCISTELKLSQAKP 243
            ...|...||     |....:|:|:....|   ..|..| ||....:..||...|.|..||.:..
Human   154 GEKLYVCIECGRAFVQKPEFITHQKTHMREKPYKCNECGKSFFQVSSLFRHHRIHTGEKLYECS- 217

  Fly   244 STDEVQIEAENENPISSD---HDLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAES 305
                   |.....|.:||   |:.|...|..:  |..|.|      :|.:...|
Human   218 -------ECGKGFPYNSDLSIHEKIHTGERHH--ECTDCG------KAFTQKST----------- 256

  Fly   306 PAAQDPLSVALGAKIFKELLDQYTGKE--------KARLRKGAPIA-------SKPK-------- 347
                        .||.:::   :||:.        :|.::|...||       .||.
Human   257 ------------LKIHQKI---HTGERSYICIECGQAFIQKTQLIAHRRIHSGEKPYECNNCGKS 306

  Fly   348 --AKEKAAGEQKPKRSANPKTKEE--------RNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRI 402
              :|.:....|:......|....|        .|||...:::::..:.:|.:||:||.....|.|
Human   307 FISKSQLQVHQRVHTRVKPYICTEYGKVFSNNSNLITHEKIQSREKSSICTECGKAFTYRSELII 371

  Fly   403 HMLRHTRTKNYQCTECPKTFYD------------------------AYMRNMHI---RIRHRGET 440
            |...||..|.|:|::|.:.|..                        |::|..|:   :|.|.||.
Human   372 HQRIHTGEKPYECSDCGRAFTQKSALTVHQRIHTGEKSYICMKCGLAFIRKAHLITHQIIHTGEK 436

  Fly   441 PFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYAL 505
            |:.||.|.:.|.     .|.:..||        |||:....|       |.|..|.|.:.::..|
Human   437 PYKCGHCGKLFT-----SKSQLHVH--------KRIHTGEKP-------YVCNKCGKAFTNRSNL 481

  Fly   506 GWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTG 569
            ..|.|:||...:|.|.:|.|:::..:.|..|:..|. ::|.:|:.|.|.|.|::.|..|:.||||
Human   482 ITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSNLNIHQKIHTG 546

  Fly   570 ERPYWCEVCNVNFRYK----YNMKSHANSK 595
            ||.|.|..|...|..|    .:.|.|...|
Human   547 ERQYECHECGKAFNQKSILIVHQKIHTGEK 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	20/81 (25%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	7/47 (15%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	6/25 (24%)
		C2H2 Zn finger	575..591	CDD:275368	5/19 (26%)
ZNF585B	NP_689492.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368	4/24 (17%)
		COG5048	156..529	CDD:227381	99/434 (23%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	5/27 (19%)
		zf-H2C2_2	228..253	CDD:290200	8/32 (25%)
		C2H2 Zn finger	244..264	CDD:275368	6/51 (12%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..320	CDD:275368	2/19 (11%)
		C2H2 Zn finger	328..347	CDD:275368	4/18 (22%)
		COG5048	335..768	CDD:227381	74/261 (28%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		zf-H2C2_2	368..393	CDD:290200	10/24 (42%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		zf-H2C2_2	424..449	CDD:290200	10/29 (34%)
		C2H2 Zn finger	440..460	CDD:275368	9/32 (28%)
		zf-H2C2_2	455..477	CDD:290200	10/36 (28%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		zf-H2C2_2	508..533	CDD:290200	8/24 (33%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		zf-H2C2_2	565..589	CDD:290200	2/11 (18%)
		C2H2 Zn finger	580..600	CDD:275368
		zf-H2C2_2	592..617	CDD:290200
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	636..656	CDD:275368
		zf-H2C2_2	648..673	CDD:290200
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_2	676..700	CDD:290200
		C2H2 Zn finger	692..712	CDD:275368
		zf-H2C2_2	705..729	CDD:290200
		C2H2 Zn finger	720..740	CDD:275368
		zf-H2C2_2	732..757	CDD:290200
		C2H2 Zn finger	748..768	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010