DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and AZF1

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	394	Identity:	83/394 - (21%)
Similarity:	145/394 - (36%)	Gaps:	111/394 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 NENPISS----------DHDLISDTENTN----VEEIEDAGGDHVEDEATSDDQTSQEAVDEVAE 304
            |:|.|:|          ||.|.|....:|    ::|||.....|:.||   |:.:|
Yeast   384 NDNSINSATSTNIPNQEDHSLASTDTTSNSRKDLKEIEQRLRKHLNDE---DNYSS--------- 436

  Fly   305 SPAAQDPL---SVALGAKIFKELLDQYTGKEKARLRK------------GAPIASKPKAKEKA-- 352
              |...||   .|..|::...:.:|: :|.:...::|            ..|....|.:|:.:
Yeast   437 --AISRPLDKNDVIEGSEGLNKHIDE-SGMQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKDNSTS 498

  Fly   353 ---------AGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHT 408
                     :|::.|....:..:.:..|||...::         ||            :.::...
Yeast   499 AEGAAMANFSGKEPPIPDISSVSDDATNLIGATKV---------DQ------------LMLIIQA 542

  Fly   409 RTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIV 473
            |.|.:  ||...|..|             |:..|     ::|.           ::......|:.
Yeast   543 RKKGF--TEKVNTTQD-------------GDLLF-----NQTM-----------DILPPKSELVG 576

  Fly   474 KRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEM 538
            ....||.....|...:::|..|.:.::....|..|::||.....:.|..|.|.::....|:.||.
Yeast   577 GVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHER 641

  Fly   539 THE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWC--EVCNVNFRYKYNMKSHANSKMHQDN 600
            .|. ::|..||:|.|.|.::..|..|.:.|...:|:.|  |.||..|....|||:|.| :.|::.
Yeast   642 LHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAHQN-RFHKET 705

  Fly   601 ARKL 604
            ...|
Yeast   706 LNAL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	2/21 (10%)
		C2H2 Zn finger	387..407	CDD:275368	2/19 (11%)
		zf-H2C2_2	399..422	CDD:290200	4/22 (18%)
		C2H2 Zn finger	415..436	CDD:275368	4/20 (20%)
		C2H2 Zn finger	444..460	CDD:275368	1/15 (7%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	10/24 (42%)
		C2H2 Zn finger	575..591	CDD:275368	8/17 (47%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	83/394 (21%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		C2H2 Zn finger	679..702	CDD:275368	10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000