DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6689 and ZNF594

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_115919.1	Gene:	ZNF594 / 84622	HGNCID:	29392	Length:	807	Species:	Homo sapiens

Alignment Length:	621	Identity:	148/621 - (23%)
Similarity:	211/621 - (33%)	Gaps:	168/621 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KNPCICIEHFKDEDIEGSLKFEMGLAKKRTLRPGAVP--C--VNKSQESGSDRARKERSQRRRNQ 115
            |.|.||.|..||      ......|.:.:.:..|..|  |  ..|:.:..|:....:|...|...
Human   180 KKPYICHECGKD------FNQSSNLVRHKQIHSGGNPYECKECGKAFKGSSNLVLHQRIHSRGKP 238

  Fly   116 EL---VAELLAEEEAKLIHPE-------------ATSFEQDSVYLSETVTMELDP----LSGEEK 160
            .|   ..:..::....:||..             ...|.|.|         .|.|    .:||:.
Human   239 YLCNKCGKAFSQSTDLIIHHRIHTGEKPYECYDCGQMFSQSS---------HLVPHQRIHTGEKP 294

  Fly   161 LEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAI 225
            |    ||..|...|.           .:|.|..|..:.||    .||.|    |..|........
Human   295 L----KCNECEKAFR-----------QHSHLTEHQRLHSG----EKPYE----CHRCGKTFSGRT 336

  Fly   226 DFREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATS 290
            .|          |...:....| :|| |.|...|.|            ||:.:....|.|::|..
Human   337 AF----------LKHQRLHAGE-KIE-ECEKTFSKD------------EELREEQRIHQEEKAYW 377

  Fly   291 DDQ-------TSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKA 348
            .:|       ||.....:|..:  .:.|.......|.|.:..|..   ...|:..|    .||..
Human   378 CNQCGRNFQGTSDLIRHQVTHT--GEKPYECKECGKTFNQSSDLL---RHHRIHSG----EKPCV 433

  Fly   349 KEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNY 413
            ..|..   |..|.::       :|||..::......:.|.:||:||....:|..|...||..|.|
Human   434 CSKCG---KSFRGSS-------DLIRHHRVHTGEKPYECSECGKAFSQRSHLVTHQKIHTGEKPY 488

  Fly   414 QCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHES---------------- 462
            |||||.|.|....:...|.|| |.||.|:.|..|.:.|.:..|..||:|
Human   489 QCTECGKAFRRRSLLIQHRRI-HSGEKPYECKECGKLFIWRTAFLKHQSLHTGEKLECEKTFSQD 552

  Fly   463 -------EVHNAAP------------------RLIVKRINPKPMPKPRESVRYQCKLCQKHYASK 502
                   ::|..|.                  |..|.....||         |:||.|.|.:...
Human   553 EELRGEQKIHQEAKAYWCNQCGRAFQGSSDLIRHQVTHTREKP---------YECKECGKTFNQS 608

  Fly   503 YALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELI 566
            ..|..|.:.|:....|.|.:|.||:...:.|.:|...|. ::|.:|..|.|.|.||:.|..|:.|
Human   609 SDLLRHHRIHSGEKPYVCNKCGKSFRGSSDLIKHHRIHTGEKPYECSECGKAFSQRSHLATHQKI 673

  Fly   567 HTGERPYWCEVCNVNFRYK----YNMKSHANSKMHQ 598
            ||||:||.|..|...||.:    .:.:.|:..|.::
Human   674 HTGEKPYQCSECGNAFRRRSLLIQHRRLHSGEKPYE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	11/44 (25%)
		zf-AD	167..240	CDD:214871	15/72 (21%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	415..436	CDD:275368	9/20 (45%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	6/26 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/19 (21%)
ZNF594	NP_115919.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		COG5048	96..518	CDD:227381	97/419 (23%)
		C2H2 Zn finger	105..121	CDD:275368
		C2H2 Zn finger	129..149	CDD:275368
		C2H2 Zn finger	157..177	CDD:275368
		C2H2 Zn finger	185..205	CDD:275368	5/25 (20%)
		C2H2 Zn finger	213..233	CDD:275368	4/19 (21%)
		C2H2 Zn finger	241..261	CDD:275368	2/19 (11%)
		C2H2 Zn finger	269..289	CDD:275368	5/28 (18%)
		C2H2 Zn finger	297..317	CDD:275368	6/30 (20%)
		C2H2 Zn finger	325..345	CDD:275368	4/29 (14%)
		C2H2 Zn finger	351..370	CDD:275370	7/31 (23%)
		COG5048	378..779	CDD:227381	94/361 (26%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		zf-H2C2_2	390..415	CDD:290200	4/26 (15%)
		C2H2 Zn finger	406..426	CDD:275368	4/22 (18%)
		C2H2 Zn finger	434..454	CDD:275368	6/29 (21%)
		zf-H2C2_2	446..471	CDD:290200	8/24 (33%)
		C2H2 Zn finger	462..482	CDD:275368	7/19 (37%)
		zf-H2C2_2	474..499	CDD:290200	13/24 (54%)
		C2H2 Zn finger	490..510	CDD:275368	9/20 (45%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	2/19 (11%)
		zf-H2C2_2	582..607	CDD:290200	9/33 (27%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		zf-H2C2_2	610..633	CDD:290200	7/22 (32%)
		C2H2 Zn finger	626..646	CDD:275368	6/19 (32%)
		zf-H2C2_2	638..663	CDD:290200	8/24 (33%)
		C2H2 Zn finger	654..674	CDD:275368	8/19 (42%)
		zf-H2C2_2	666..691	CDD:290200	12/24 (50%)
		C2H2 Zn finger	682..702	CDD:275368	4/19 (21%)
		C2H2 Zn finger	710..730	CDD:275368	148/621 (24%)
		C2H2 Zn finger	736..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100