Protein Alignment CG6689 and ZNF91

DIOPT Version :10

• Sequence 1: NP_650051.1
• Gene: CG6689 / 41345
• FlyBaseID: FBgn0037877
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_003421.2
• Gene: ZNF91 / 7644
• HGNCID: 13166
• Length: 1191
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 139/611 - (22%)
• Similarity: 223/611 - (36%)
• Gaps: 159/611 - (26%)

  Fly    33 KCPDTFKAWLAFCGYTEESLKLKNPCICIEHFKDEDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQ 97
            ||.:..||:|    ::....:.|......:.:|.|:...:......|||.:.:..|..|  .|.:
Human   267 KCEECGKAFL----WSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKP--YKCE 325

  Fly    98 ESGSDRAR-------------------KERSQRRRNQELVAELLAEEEAKLIHPEATSF---EQD 140
            |.|...:|                   ||..:...|...:|      ..|:.|.|...:   |.|
Human   326 ECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLA------NHKITHTEEKPYKCKECD 384

  Fly   141 SVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGV---- 201
            ..:...:...:...:...|||.:.::|...:|              .:|.|..|..:.:|.
Human   385 KAFKRLSTLTKHKIIHAGEKLYKCEECGKAFN--------------RSSNLTIHKFIHTGEKPYK 435

  Fly   202 ---------WIS--------HKPDEPRLMCPAC-KSALDQAIDFREMCISTELKLSQAKPSTDEV 248
                     |.|        |..::| ..|..| |:.:..:...|...|.|     ..||...|.
Human   436 CEECGKAFNWSSSLTKHKRFHTREKP-FKCKECGKAFIWSSTLTRHKRIHT-----GEKPYKCEE 494

  Fly   249 QIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLS 313
            ..:|..::...:.|.:|...|..  .:.|:.|
Human   495 CGKAFRQSSTLTKHKIIHTGEKP--YKFEECG--------------------------------- 524

  Fly   314 VALGAKIFKELLDQYTGKEKARLRKGAPIASKPKA-KEKAAGEQKPKRSANPKTKEERNLIRRAQ 377
                 |.|::.|         .|.|...|.|:.|. |.|..|:         ..|:...|.....
Human   525 -----KAFRQSL---------TLNKHKIIHSREKPYKCKECGK---------AFKQFSTLTTHKI 566

  Fly   378 LRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPF 442
            :.|....:.|::||:||..|.:|..|.:.||..|:|:|.||.|.|..:.....|.|| |.||.|:
Human   567 IHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRI-HTGEKPY 630

  Fly   443 ACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGW 507
            .|..|.:.|::..|..||             |||:....|       |:||.|.|.:::...|..
Human   631 KCEECGKAFSHSSALAKH-------------KRIHTGEKP-------YKCKECGKAFSNSSTLAN 675

  Fly   508 HIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHEKRPL-QCDVCLKGFYQRTRLREHELIHTGER 571
            |..:||:...|||:.|.|::...:.|.:|::.|....| :|:.|.|.|.:.:.|..|:.|||||:
Human   676 HKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEK 740

  Fly   572 PYWCEVCNVNFRYKYNMKSHANSKMH 597
            ||.||.|...|.:..::..|  .::|
Human   741 PYKCEECGKAFNWSSSLTKH--KRIH 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..94	CDD:214951	13/60 (22%)
		zf-AD	166..241	CDD:462262	16/96 (17%)
		zf-C2H2	385..407	CDD:395048	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	573..597	CDD:463736	6/23 (26%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
ZNF91	NP_003421.2	KRAB	13..73	CDD:214630
		C2H2 Zn finger	155..176	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368	5/23 (22%)
		zf-H2C2_2	281..305	CDD:463886	3/23 (13%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	320..708	CDD:227381	106/494 (21%)
		C2H2 Zn finger	324..344	CDD:275368	3/19 (16%)
		C2H2 Zn finger	352..372	CDD:275368	5/25 (20%)
		C2H2 Zn finger	380..400	CDD:275368	2/19 (11%)
		C2H2 Zn finger	408..428	CDD:275368	5/33 (15%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		C2H2 Zn finger	464..484	CDD:275368	4/19 (21%)
		C2H2 Zn finger	492..512	CDD:275368	3/19 (16%)
		C2H2 Zn finger	520..540	CDD:275368	7/66 (11%)
		C2H2 Zn finger	548..568	CDD:275368	4/28 (14%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		C2H2 Zn finger	604..624	CDD:275368	8/20 (40%)
		COG5048	628..1069	CDD:227381	48/159 (30%)
		C2H2 Zn finger	632..652	CDD:275368	8/32 (25%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		C2H2 Zn finger	688..708	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..736	CDD:275368	6/19 (32%)
		C2H2 Zn finger	744..764	CDD:275368	5/21 (24%)
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	885..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	968..988	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1024..1044	CDD:275368
		C2H2 Zn finger	1052..1072	CDD:275368
		SFP1	<1075..1154	CDD:227516
		C2H2 Zn finger	1080..1100	CDD:275368
		C2H2 Zn finger	1108..1128	CDD:275368
		C2H2 Zn finger	1136..1156	CDD:275368