DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp605

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001157468.1	Gene:	Zfp605 / 675812	MGIID:	2444933	Length:	694	Species:	Mus musculus

Alignment Length:	630	Identity:	144/630 - (22%)
Similarity:	218/630 - (34%)	Gaps:	166/630 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RNFSDCRSKRNA---------AQQQRLGFFRFPKCPDTF--KAWLAF--CGYTEESLKLKNPCIC 60
            |...||...|.|         .|:...|.|...:|...|  |:.|..  ..:|||     .||.|
Mouse   171 RKCHDCNKYRKANSNESQLVTKQRTHSGIFLCMECGRIFNKKSQLIVHQRNHTEE-----KPCQC 230

  Fly    61 IEHFK----------------DEDIEGSLKF---EMGLAKKRTLRPGAVPCVNKSQESGSDRARK 106
            ..:.|                .|:.|....|   .:||.::|| ..|..|...     |...:||
Mouse   231 NGYGKTFAQKSQLAIHQKTHSGEEPERQKAFGGKSLGLQQQRT-HTGQKPYAR-----GKTYSRK 289

  Fly   107 ERSQRRRNQELV---------AELLAEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLE 162
            ....|......|         .|:.:::...:||......|:.
Mouse   290 PTQNRPAMSHAVHKPYRCGDCGEVFSQKLKLIIHRSTHPGEKP---------------------- 332

  Fly   163 ELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQ-AID 226
              .||..|...|.           .||.|:.|..       ||:..:| .:|..|:.|..: ::.
Mouse   333 --YKCSECRKAFF-----------WNSQLITHRR-------SHRGKKP-YVCSECEKAFRRNSLL 376

  Fly   227 FREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATSD 291
            .|...|.|     ..||.......||....|..:.|.:      |:..|.:..|.:.|
Mouse   377 IRHQRIHT-----GEKPHRSRECGEAFIGKPQLAKHHM------THTGEKKCYGFEEV------- 423

  Fly   292 DQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAGEQ 356
             ...:..:....:|...:.|...|...|||         .||::|          ...:|:...:
Mouse   424 -FFKKSKLMRHQKSHLGEKPNRCAEFGKIF---------PEKSQL----------LTHQKSHSGE 468

  Fly   357 KPKRSAN-PKTKEERNLI---RRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTE 417
            :|.|.|. .||...|:.:   :|.....||  :.|:.||:||....::..|...||..|.::|.:
Mouse   469 RPYRCAECGKTFPGRSSLLSHQRTHTGEKP--YKCNLCGRAFSQRSSIISHQRTHTGEKPFKCGD 531

  Fly   418 CPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMP 482
            |.|.|.:. ...:|.:..|.||.||.|..|.:.||:.....:|: .:|..              .
Mouse   532 CGKAFTEK-SNLLHHKRTHTGEKPFGCSDCGKAFAWKPHLLQHQ-RIHTG--------------E 580

  Fly   483 KPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQ 546
            ||     ::|..|.|.:..|..|..|.:.||....|||..|.|::.:..:|..|:..|. :||..
Mouse   581 KP-----FECSECGKAFVQKVQLIKHQRHHTGEKIYKCSSCEKAFFEKTQLTIHQKIHTGERPYT 640

  Fly   547 CDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSH 591
            |..|.:.|.:.:.|..|:.|||.::.|.|..|...|    |.|||
Mouse   641 CGECGRSFTRNSHLMRHKPIHTRDKCYRCSQCGSIF----NKKSH 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	28/118 (24%)
		zf-AD	167..240	CDD:214871	16/73 (22%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..422	CDD:290200	7/22 (32%)
		C2H2 Zn finger	415..436	CDD:275368	5/20 (25%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	5/19 (26%)
		zf-met	574..597	CDD:289631	7/18 (39%)
		C2H2 Zn finger	575..591	CDD:275368	5/15 (33%)
Zfp605	NP_001157468.1	KRAB	7..62	CDD:214630
		C2H2 Zn finger	173..196	CDD:275368	5/22 (23%)
		C2H2 Zn finger	202..222	CDD:275368	4/19 (21%)
		C2H2 Zn finger	230..250	CDD:275368	2/19 (11%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		COG5048	331..693	CDD:227381	107/459 (23%)
		C2H2 Zn finger	335..355	CDD:275368	7/37 (19%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	4/25 (16%)
		C2H2 Zn finger	445..465	CDD:275368	8/38 (21%)
		C2H2 Zn finger	473..493	CDD:275368	5/19 (26%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		C2H2 Zn finger	529..549	CDD:275368	5/20 (25%)
		C2H2 Zn finger	557..577	CDD:275368	5/20 (25%)
		C2H2 Zn finger	585..605	CDD:275368	6/19 (32%)
		C2H2 Zn finger	613..633	CDD:275368	5/19 (26%)
		C2H2 Zn finger	641..661	CDD:275368	5/19 (26%)
		C2H2 Zn finger	669..689	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100