DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp600

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001171016.1	Gene:	Zfp600 / 667666	MGIID:	3705222	Length:	737	Species:	Mus musculus

Alignment Length:	384	Identity:	93/384 - (24%)
Similarity:	152/384 - (39%)	Gaps:	58/384 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EVQIEAENENPISSDHDLISDTENTNVEE------IEDAGGD--------------HVEDEATSD 291
            :|.:|..|......:|.:..:.|...|.|      :.:.|.:              |...|:|..
Mouse    55 DVMLENYNNLLFVENHCICGNYEKEKVLEQETQHIVNEHGHNRKKSSKCNEVRNVIHESSESTPY 119

  Fly   292 DQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAGEQ 356
            :...::|.  :..|...:.......|...:|:.::...|.....|.:|..|..|...:.|...|.
Mouse   120 NTNHRDAT--LQSSNLKRHKTGTTKGVCTYKDCVNCLKGSSIISLNQGTHIEKKEHNRNKNLDEV 182

  Fly   357 KPKRSANPKTK------------EERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTR 409
            ...|..|.:..            :..||..:.::.....:::..:..:.|....:|.||...|:.
Mouse   183 LVSRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYIYSESDKCFTQPSHLSIHHTIHSG 247

  Fly   410 TKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVK 474
            .|.|:|:||.|.|.|......|.|| |.||.|:.|..|.:.|......:||: .:|..
Mouse   248 EKPYKCSECDKCFTDKCTLRKHQRI-HTGEKPYKCSECDKCFTDKCTLRKHQ-RIHTG------- 303

  Fly   475 RINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMT 539
                   .||     |:|..|.|.:..|.:|..|.:.||....|||..|.|.::.|:.|..|...
Mouse   304 -------EKP-----YKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHRRI 356

  Fly   540 HE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMH 597
            |. ::|.:|..|.|.|..:..||:|:.|||||:||.|..|:..|..|:.::.|  .::|
Mouse   357 HSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTEKFTLRKH--QRIH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	4/21 (19%)
		C2H2 Zn finger	387..407	CDD:275368	4/19 (21%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	9/20 (45%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	5/22 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Zfp600	NP_001171016.1	KRAB	28..>70	CDD:214630	3/14 (21%)
		KRAB	28..67	CDD:279668	3/11 (27%)
		C2H2 Zn finger	197..217	CDD:275368	2/19 (11%)
		C2H2 Zn finger	229..245	CDD:275368	4/15 (27%)
		C2H2 Zn finger	253..273	CDD:275368	9/20 (45%)
		zf-H2C2_2	266..289	CDD:290200	9/23 (39%)
		C2H2 Zn finger	281..301	CDD:275368	5/20 (25%)
		zf-H2C2_2	294..317	CDD:290200	9/42 (21%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	321..346	CDD:290200	9/24 (38%)
		COG5048	333..730	CDD:227381	30/83 (36%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..401	CDD:290200	12/22 (55%)
		C2H2 Zn finger	393..413	CDD:275368	5/21 (24%)
		zf-H2C2_2	406..429	CDD:290200	2/10 (20%)
		C2H2 Zn finger	421..441	CDD:275368
		zf-H2C2_2	433..457	CDD:290200
		C2H2 Zn finger	449..469	CDD:275368
		C2H2 Zn finger	477..497	CDD:275368
		C2H2 Zn finger	505..525	CDD:275368
		zf-H2C2_2	517..542	CDD:290200
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		zf-H2C2_2	573..597	CDD:290200
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..665	CDD:275368
		zf-H2C2_2	657..682	CDD:290200
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	701..721	CDD:275368
		zf-H2C2_2	713..737	CDD:290200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100