DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6689 and CG4820

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001097748.1	Gene:	CG4820 / 41344	FlyBaseID:	FBgn0037876	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	107/472 - (22%)
Similarity:	170/472 - (36%)	Gaps:	161/472 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 CRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMC 231
            ||||.....|| ....:|.||...||..:..|:..|:.:..|.|..:|..|:..|.|...||..|
  Fly     5 CRTCGKTVVAD-ECLQIFTPAGRKLLQCVRSITNCWLQNVQDLPNHICTDCQVLLSQVQKFRRRC 68

  Fly   232 ISTE---------LKLSQAKPSTDEVQI-EAENENPISSDHDLISDTENTNVEEIEDAGGDHVED 286
            ...|         :.|.:|..:.::::: :|...:|:..| :|:| ..:..:|.|
  Fly    69 AKIEKYFARRRRRMNLGEAPAAMEQLRVQQAAAPDPLGID-ELMS-ASDIKIEPI---------- 121

  Fly   287 EATSDDQTSQEAVDEVAESPAAQDPLSVAL------GAKIFKELLDQY---------TGKEKA-- 334
                     |..::|..::|..::.|..||      |..|. .|.:.|         |..|.|
  Fly   122 ---------QLQMEEDPQAPYPENQLEQALSYGNAPGEDIL-PLPEDYGEAQTEVATTTNEPAQR 176

  Fly   335 RLRKGAPIASKPKAKE--------KAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCG 391
            |.:..|.|.||.....        |...:::|||           ::.|....|||  .:|:.||
  Fly   177 RSKNTAKIKSKKHTMRVGRKLIHVKVIDDKQPKR-----------IVDRNGPSAKP--CICEHCG 228

  Fly   392 QAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGA 456
            :.|:.:.||.:|:||||.||.::|.:|.:..|..::...| :::|. |.|:||.||...::...:
  Fly   229 RQFKDTSNLHVHLLRHTGTKPFECDQCHQKCYTLHLLRRH-QLKHT-EGPYACTFCGLEYSTNSS 291

  Fly   457 RQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQ 521
            |.:||.|
  Fly   292 RVRHERE---------------------------------------------------------- 298

  Fly   522 RCSKSYSDPNKLKRHEMTHEKRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKY 586
                                       .|.||   |....:.|:|..|||.:.||||::.|....
  Fly   299 ---------------------------ACKKG---RAPQSKWEIIKKGERTFHCEVCDLWFLRAG 333

  Fly   587 NMKSHANSKMHQDNARK 603
            |...|.||..|.:|.|:
  Fly   334 NFTQHINSSSHIENERR 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	24/81 (30%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	11/22 (50%)
		C2H2 Zn finger	415..436	CDD:275368	4/20 (20%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	0/19 (0%)
		C2H2 Zn finger	520..540	CDD:275368	0/19 (0%)
		C2H2 Zn finger	547..567	CDD:275368	5/19 (26%)
		zf-met	574..597	CDD:289631	9/22 (41%)
		C2H2 Zn finger	575..591	CDD:275368	6/15 (40%)
CG4820	NP_001097748.1	zf-AD	4..75	CDD:285071	23/70 (33%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	4/20 (20%)
		C2H2 Zn finger	279..297	CDD:275368	5/17 (29%)
		C2H2 Zn finger	322..339	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960