DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6689 and Phs

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_648789.3	Gene:	Phs / 39697	FlyBaseID:	FBgn0036522	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	146/688 - (21%)
Similarity:	241/688 - (35%)	Gaps:	199/688 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ICIEHFKDEDIEGSLK----------------------FEMGLAKKRTLRPGAVPCVN------- 94
            |...||:.|.:|.|.:                      .|||..|         ||..
  Fly   172 ILSRHFQLEHVEKSKRKRGKTKAAAEEPMVTPPLIIDPLEMGQLK---------PCAQLLVQGES 227

  Fly    95 --------KSQESGSDRARKERSQRRRNQELVAELLAEEE-------AKLIHPEATSFEQDSVYL 144
                    .||.....|.::..||:....:|   |:.:||       |.:..|.|.:..:.:..|
  Fly   228 VLQLCLACNSQFVDVVRFQEHLSQQHGYFQL---LVPKEEPTDLPPHAMVTIPGALALNKANAQL 289

  Fly   145 S------ETVTMELD-----PLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVI 198
            .      ||...|.|     |.:.....|:|    |..||..|...|:.:...::|.:   .::|
  Fly   290 QLPIPAPETPPPEQDGKEAPPSNASNDKEDL----TMINDMVAVIAAERVKKTSSSKV---NKMI 347

  Fly   199 SGVWISHKPDEPRLMCPACKSALDQA--IDFREMCISTE-----LKLSQAKPSTDEVQIEAENEN 256
            ..:.:..|....|....:.:...|.|  .|.::.....|     |:..|||.::::.:..|...|
  Fly   348 IKLPMPKKRGRKRTKPESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENGATQSN 412

  Fly   257 PI----------SSDHDLISDTENTNVEEIEDA---GGDHVE---------------DEA----- 288
            .:          ..|....:....||.:.:|:|   ..|:.|               |||
  Fly   413 NVVKVQQNAKGSKKDGTQSAQKSETNPKHLENAETNSKDNTESVALKETIHDKQLTIDEAGKAGT 477

  Fly   289 TSDDQTSQEAVDEVAESPAA----------QDPLSVALGAKIFKELLDQYTGKEKARL----RKG 339
            ..||.::|:.:|: :|:.|.          |.|:.   .||..:::.::.|...|.:.    ||.
  Fly   478 QKDDNSNQKQLDK-SEANAGKSKMVDQVHQQMPVE---SAKDHQQMTEEPTNSTKRKRGRKERKS 538

  Fly   340 -----APIASKPKAKEKAAGEQKPKRSA-----------------------------------NP 364
                 .|:..|...:|....|::.::|.                                   |.
  Fly   539 PTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEEEDDDEVEEAEVDDDSSATISPHNS 603

  Fly   365 KTKEERNLIRRAQLRAKPPNFV-----CDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYD 424
            .|.|....|:|........|.:     |:.||:.|:....::.|:..||..|.|.|.:|.:.| .
  Fly   604 STDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLRLHTGEKPYVCGQCGRAF-R 667

  Fly   425 AYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVR 489
            ..||.:..::|||.|..:.|..||...|     .|.:..:|               |...:...|
  Fly   668 LKMRLVEHQLRHRAEKAYKCDICSMPLA-----TKQDLSLH---------------MRHHKNDRR 712

  Fly   490 YQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTH-EKRPLQCDVCLKG 553
            |:|..|.|.:.....|..|::.||....|.|..|.|::.....|..|..|| ..:|:||::|.|.
  Fly   713 YKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKR 777

  Fly   554 FYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSH 591
            |.::..:|.|...||||:||.|:.|...:..:.|:..|
  Fly   778 FARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRH 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	12/73 (16%)
		zf-AD	167..240	CDD:214871	14/79 (18%)
		zf-C2H2	385..407	CDD:278523	5/26 (19%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..422	CDD:290200	7/22 (32%)
		C2H2 Zn finger	415..436	CDD:275368	5/20 (25%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	4/18 (22%)
		C2H2 Zn finger	575..591	CDD:275368	3/15 (20%)
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	55/213 (26%)
		C2H2 Zn finger	631..651	CDD:275368	5/19 (26%)
		zf-H2C2_2	644..666	CDD:290200	7/21 (33%)
		zf-H2C2_2	699..724	CDD:290200	7/39 (18%)
		zf-C2H2	713..735	CDD:278523	6/21 (29%)
		C2H2 Zn finger	715..735	CDD:275368	5/19 (26%)
		zf-H2C2_2	727..750	CDD:290200	8/22 (36%)
		C2H2 Zn finger	743..763	CDD:275368	5/19 (26%)
		zf-H2C2_2	755..780	CDD:290200	10/24 (42%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		zf-H2C2_2	783..808	CDD:290200	10/24 (42%)
		C2H2 Zn finger	799..816	CDD:275370	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3304
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.950