DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp26

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001102465.2	Gene:	Zfp26 / 367033	RGDID:	1565847	Length:	956	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	120/509 - (23%)
Similarity:	178/509 - (34%)	Gaps:	126/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDE 209
            |..:|..|...:||:..|    |..|...||           .:|.||.||...:|    .||.|
  Rat   437 SSYLTTHLRTHTGEKPFE----CNICGKAFT-----------RSSYLLGHIRTHTG----EKPYE 482

  Fly   210 PRLMCPACKSALDQAIDFREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVE 274
                |..|..|...         .:.|.:...|.:.:......|.|...:|...|.
  Rat   483 ----CKVCGKAFSG---------RSWLTIHLRKHTGERPYPCTECEKAFTSFAQLT--------- 525

  Fly   275 EIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKE---KARL 336
                   :|::..........:........|...:....:..|.|.:|   ..|.||:   ::.|
  Rat   526 -------EHIKTHTGEKPFRCKVCARTFRNSSCLKTHFRIHTGIKPYK---CNYCGKDFTARSGL 580

  Fly   337 RKGAPIASKPKAKE-KAAGE-----------------QKPKR--SANPKTKEERNLIRRAQLRAK 381
            .|...|.:..|..| |..|:                 :||..  ..........:|:...:....
  Rat   581 TKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVGHLRTHTG 645

  Fly   382 PPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIR----------- 435
            ...|.|:||.:.|..|..|||||..||..|.|:|.||.|||.:......|||..
  Rat   646 EKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKEC 710

  Fly   436 ----------------HRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKP 484
                            |..|.||.|..|:::|....:.:.| ..:|...              ||
  Rat   711 GKGFISFAQLTVHIKTHSSERPFQCKVCTKSFRNSSSLETH-FRIHTGV--------------KP 760

  Fly   485 RESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCD 548
                 |:|..|.|.:.::..|..|:::||...:|.||.|.|::|..:.|..|..:|: ::|.:||
  Rat   761 -----YKCSYCGKDFTARSGLTIHLRNHTGEKSYACQECGKAFSTSSGLIAHIRSHKGEKPFECD 820

  Fly   549 VCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFR----YKYNMKSHANSKMHQ 598
            .|.|.|...:.|..|..|||||:|:.|.||...|.    ...:|::|...|..|
  Rat   821 HCGKAFASSSYLNVHLKIHTGEKPFQCTVCGKTFTCSSYLPVHMRTHTGEKPFQ 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	17/72 (24%)
		zf-C2H2	385..407	CDD:278523	11/21 (52%)
		C2H2 Zn finger	387..407	CDD:275368	10/19 (53%)
		zf-H2C2_2	399..422	CDD:290200	13/22 (59%)
		C2H2 Zn finger	415..436	CDD:275368	9/47 (19%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	7/26 (27%)
		C2H2 Zn finger	575..591	CDD:275368	5/19 (26%)
Zfp26	NP_001102465.2	KRAB	104..162	CDD:214630
		C2H2 Zn finger	288..308	CDD:275368
		COG5048	338..751	CDD:227381	77/364 (21%)
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368	3/9 (33%)
		C2H2 Zn finger	455..475	CDD:275368	9/30 (30%)
		C2H2 Zn finger	483..503	CDD:275368	4/28 (14%)
		C2H2 Zn finger	511..531	CDD:275368	5/35 (14%)
		C2H2 Zn finger	539..559	CDD:275368	1/19 (5%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		COG5048	591..>918	CDD:227381	81/304 (27%)
		C2H2 Zn finger	595..615	CDD:275368	2/19 (11%)
		C2H2 Zn finger	623..643	CDD:275368	1/19 (5%)
		C2H2 Zn finger	651..671	CDD:275368	10/19 (53%)
		C2H2 Zn finger	679..699	CDD:275368	9/19 (47%)
		C2H2 Zn finger	707..727	CDD:275368	0/19 (0%)
		C2H2 Zn finger	735..755	CDD:275368	4/20 (20%)
		C2H2 Zn finger	763..783	CDD:275368	5/19 (26%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	819..839	CDD:275368	7/19 (37%)
		C2H2 Zn finger	847..867	CDD:275368	5/19 (26%)
		C2H2 Zn finger	875..895	CDD:275368	120/509 (24%)
		C2H2 Zn finger	903..923	CDD:275368
		C2H2 Zn finger	931..947	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100