DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6689 and ZNF445

DIOPT Version :10

Sequence 1:NP_650051.1 Gene:CG6689 / 41345 FlyBaseID:FBgn0037877 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_852466.1 Gene:ZNF445 / 353274 HGNCID:21018 Length:1031 Species:Homo sapiens


Alignment Length:667 Identity:130/667 - (19%)
Similarity:205/667 - (30%) Gaps:236/667 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 KCPDTFKAWLAFCGYT----------------EESLKLKNPCICIEHFKDEDIEGSLKFEMGLAK 81
            ||.|        ||.|                |::.|.:   :|.:.|         ::....|:
Human   486 KCSD--------CGRTFSHSSHLAYHQRLHTQEKAFKCR---VCGKAF---------RWSSNCAR 530

  Fly    82 KRTLRPGAVP-----CVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAKLIHPEATSFEQDS 141
            ...:..|..|     |         ::|.:..|..|.::|             .|.:....|.:.
Human   531 HEKIHTGVKPYKCDLC---------EKAFRRLSAYRLHRE-------------THAKKKFLELNQ 573

  Fly   142 VYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHK 206
            ...:.|.:...|...|::..|:|..|..|...|           ...|.:|.|..:       |.
Human   574 YRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSF-----------HCKSYVLEHQRI-------HT 620

  Fly   207 PDEPRLMCPACKSALDQAIDF-REMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTEN 270
            .::| ..|..|:.......:| |.|.:..|.|.                                
Human   621 QEKP-YKCTKCRKTFRWRSNFTRHMRLHEEEKF-------------------------------- 652

  Fly   271 TNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLSVALGAKIF---KELLDQ---YT 329
                        :.:||.....:.|.:. .:...:||.:.........|.|   |.|:|.   :|
Human   653 ------------YKQDECREGFRQSPDC-SQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHT 704

  Fly   330 GKEKARLRK-GAPIASKPK---AKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQC 390
            |::..:... |...|.:..   .|:|.|.::||:  ..|...::..........:|...:.|.||
Human   705 GEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPE--GGPSFSQDTVFQVPQSSHSKEEPYKCSQC 767

  Fly   391 GQAFRMSHNLRIHMLRHTRTKNYQCTECPKTF------------------YDAYMRNMHIRIRHR 437
            |:|||....|.||...||..|.|:|.||.|.|                  ||.:.......:..:
Human   768 GKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPK 832

  Fly   438 ---GETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHY 499
               ||..|.|..|.:||........|:. :|:.                   ..||:|.||.|.|
Human   833 ILTGEKRFWCQECGKTFTRKRTLLDHKG-IHSG-------------------EKRYKCNLCGKSY 877

  Fly   500 ASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTH------------------------ 540
            ...|.|..|.:.|:....:|||.|.|.:...:.|..|:..|                        
Human   878 DRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQ 942

  Fly   541 -----EKRPLQ--------------------------CDVCLKGFYQRTRLREHELIHTGERPYW 574
                 |:.||:                          |.:|.|.|.:.::|..|:..||.|||:.
Human   943 KLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFK 1007

  Fly   575 CEVCNVNFRYKYNMKSH 591
            |..|...||:..|:..|
Human  1008 CSKCGKTFRWSSNLARH 1024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6689NP_650051.1 THAP 2..94 CDD:214951 14/81 (17%)
zf-AD 166..241 CDD:462262 15/75 (20%)
zf-C2H2 385..407 CDD:395048 10/21 (48%)
C2H2 Zn finger 387..407 CDD:275368 10/19 (53%)
C2H2 Zn finger 415..436 CDD:275368 7/38 (18%)
C2H2 Zn finger 444..460 CDD:275368 4/15 (27%)
C2H2 Zn finger 492..512 CDD:275368 8/19 (42%)
C2H2 Zn finger 520..540 CDD:275368 6/19 (32%)
C2H2 Zn finger 547..567 CDD:275368 6/19 (32%)
zf-met 573..597 CDD:463736 6/19 (32%)
C2H2 Zn finger 575..591 CDD:275368 5/15 (33%)
ZNF445NP_852466.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
SCAN 51..155 CDD:128708
KRAB 234..292 CDD:214630
C2H2 Zn finger 415..451 CDD:275368
COG5048 <457..643 CDD:227381 36/217 (17%)
C2H2 Zn finger 460..479 CDD:275368
C2H2 Zn finger 487..507 CDD:275368 5/27 (19%)
C2H2 Zn finger 515..535 CDD:275368 3/31 (10%)
C2H2 Zn finger 543..563 CDD:275368 5/41 (12%)
COG5048 595..1031 CDD:227381 106/516 (21%)
C2H2 Zn finger 599..619 CDD:275368 6/37 (16%)
C2H2 Zn finger 627..647 CDD:275368 5/19 (26%)
C2H2 Zn finger 683..703 CDD:275368 5/19 (26%)
C2H2 Zn finger 711..731 CDD:275368 3/19 (16%)
C2H2 Zn finger 764..784 CDD:275368 10/19 (53%)
C2H2 Zn finger 792..812 CDD:275368 5/19 (26%)
C2H2 Zn finger 842..862 CDD:275368 5/20 (25%)
C2H2 Zn finger 870..890 CDD:275368 8/19 (42%)
C2H2 Zn finger 898..918 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..939 3/27 (11%)
C2H2 Zn finger 953..972 CDD:275368 0/18 (0%)
C2H2 Zn finger 980..1000 CDD:275368 6/19 (32%)
C2H2 Zn finger 1008..1028 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

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