DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6689 and ZNF658

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001304845.1	Gene:	ZNF658 / 26149	HGNCID:	25226	Length:	1059	Species:	Homo sapiens

Alignment Length:	597	Identity:	134/597 - (22%)
Similarity:	223/597 - (37%)	Gaps:	141/597 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EHFKDEDIEGSLKFE---MGLAKK------RTLRPGAVPCVNKSQESGSDRARKERSQRRRNQEL 117
            :|:|.:.:|.|.:.:   .||..|      ::...|...|.:.......|:.......|...:..
Human   204 QHWKFQTLEESFECDGSGQGLYDKTICITPQSFLTGEKSCKDDEFRKNFDKITLFNHMRTDTRGK 268

  Fly   118 VAELLAEEEAKLIHPEATSFEQDSVYLSET----------------VTMELDPLSGEEKLEELQK 166
            .::|   .|......:.|:.|.:.|:::.|                :|.....::|....|. .|
Human   269 CSDL---NEYGTSCDKTTAVEYNKVHMAMTHYECNERGINFSRKSPLTQSQRTITGWSAFES-NK 329

  Fly   167 CRTCYNDFTADF-----RAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAID 226
            |...::..:|..     :|.|.|...|.                           |..||.|.:|
Human   330 CEENFSQSSAHIVHQKTQAGDKFGEHNE---------------------------CTDALYQKLD 367

  Fly   227 FREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATSD 291
            |                 |...:|..|::..:|.:|.....:.......|:       .....|.
Human   368 F-----------------TAHQRIHTEDKFYLSDEHGKCRKSFYRKAHLIQ-------HQRPHSG 408

  Fly   292 DQTSQEAVDEVAES-PAAQDPL---SVALGAKIFKELLDQYTGK---EKARLRKGAPIASKPK-A 348
            ::|.|  .:|.|:| .::..|:   ...:|.|:::   ....||   :.:.|.|...|.:|.| .
Human   409 EKTYQ--YEECAKSFCSSSHPIQHPGTYVGFKLYE---CNECGKAFCQNSNLSKHLRIHTKEKPC 468

  Fly   349 KEKAAGEQ-KPKRSANPKTKEERNLI--------------RRAQLRAKPPNFVCDQCGQAFRMSH 398
            .....|.. |.....:.||..|..|.              :|..:..||  :.|.:||:.|..:.
Human   469 DNNGCGRSYKSPLIGHQKTDAEMELCGGSEYGKTSHLKGHQRILMGEKP--YECIECGKTFSKTS 531

  Fly   399 NLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESE 463
            :||.|...||..|.|:|.||.|||......::|.|: |.||.|:.|..|.::|.|..|.:.|: .
Human   532 HLRAHQRIHTGEKPYECVECEKTFSHKTHLSVHQRV-HTGEKPYECNDCGKSFTYNSALRAHQ-R 594

  Fly   464 VHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYS 528
            :|..              .||     |:|..|:|.:|...||..|.:.||....|:|..|.:|::
Human   595 IHTG--------------EKP-----YECSDCEKTFAHNSALRAHHRIHTGEKPYECNECGRSFA 640

  Fly   529 DPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRY----KYNM 588
            ..:.||.|:..|. ::|.:|:.|.:.|...:.||.|:.||||.:||.|..|...|.:    |.:.
Human   641 HISVLKAHQRIHTGEKPYECNECGRSFTYNSALRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQ 705

  Fly   589 KSHANSKMHQDN 600
            :.|...|.::.|
Human   706 RIHTGEKPYECN 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	9/42 (21%)
		zf-AD	167..240	CDD:214871	12/77 (16%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	11/22 (50%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	5/15 (33%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	6/26 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/19 (21%)
ZNF658	NP_001304845.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	279..296	CDD:275368	3/16 (19%)
		C2H2 Zn finger	299..319	CDD:275368	1/19 (5%)
		C2H2 Zn finger	328..347	CDD:275368	3/18 (17%)
		C2H2 Zn finger	355..375	CDD:275368	8/63 (13%)
		COG5048	371..789	CDD:227381	100/382 (26%)
		C2H2 Zn finger	389..406	CDD:275368	1/23 (4%)
		C2H2 Zn finger	414..434	CDD:275368	4/19 (21%)
		C2H2 Zn finger	442..462	CDD:275368	4/19 (21%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		zf-H2C2_2	532..557	CDD:290200	13/24 (54%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		zf-H2C2_2	560..585	CDD:290200	9/25 (36%)
		C2H2 Zn finger	576..596	CDD:275368	6/20 (30%)
		zf-H2C2_2	588..613	CDD:290200	9/44 (20%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..641	CDD:290200	9/24 (38%)
		COG5048	628..1044	CDD:227381	28/90 (31%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		zf-H2C2_2	645..669	CDD:290200	8/23 (35%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		zf-H2C2_2	672..697	CDD:290200	12/24 (50%)
		C2H2 Zn finger	688..708	CDD:275368	4/19 (21%)
		zf-H2C2_2	700..725	CDD:290200	4/18 (22%)
		C2H2 Zn finger	716..736	CDD:275368	1/2 (50%)
		C2H2 Zn finger	744..764	CDD:275368
		zf-H2C2_2	757..781	CDD:290200
		C2H2 Zn finger	772..792	CDD:275368
		zf-H2C2_2	784..809	CDD:290200
		C2H2 Zn finger	800..820	CDD:275368
		zf-H2C2_2	812..837	CDD:290200
		C2H2 Zn finger	828..848	CDD:275368
		zf-H2C2_2	844..864	CDD:290200
		C2H2 Zn finger	856..876	CDD:275368
		zf-H2C2_2	868..892	CDD:290200
		C2H2 Zn finger	884..903	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		zf-H2C2_2	953..977	CDD:290200
		C2H2 Zn finger	968..988	CDD:275368
		zf-H2C2_2	980..1005	CDD:290200
		C2H2 Zn finger	996..1016	CDD:275368
		zf-H2C2_2	1009..1033	CDD:290200
		C2H2 Zn finger	1024..1045	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010