Protein Alignment CG6689 and ZNF281

DIOPT Version :9

• Sequence 1: NP_650051.1
• Gene: CG6689 / 41345
• FlyBaseID: FBgn0037877
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001268222.1
• Gene: ZNF281 / 23528
• HGNCID: 13075
• Length: 895
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 75/326 - (23%)
• Similarity: 121/326 - (37%)
• Gaps: 84/326 - (25%)

  Fly   236 LKLSQAKPSTDEVQIEAENENPISSDH--DLISDTENTNVEEIEDAGGDH--VEDEATSDDQTSQ 296
            :.:.|.||:..|   |.::.:.....|  .|.:..|..:.......||.|  ::|.:.......|
Human   125 VSIKQEKPADPE---EQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQ 186

  Fly   297 EAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKA-AGEQKPKR 360
            :         .||....|.|.:   ....|.:.|.|:.:.......|.:||.:.:. ..::||..
Human   187 Q---------PAQHHRDVLLSS---SSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSA 239

  Fly   361 SANPKT--KEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFY 423
            |:.|..  ..|..::..:|   ||  .:||.|..|||.|::||.|:|.||..:.:||::|...|.
Human   240 SSKPSLVGDGEGAILSPSQ---KP--HICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFI 299

  Fly   424 DAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESV 488
            ..|:...|.:| |..|.||.|..||..|
Human   300 QKYLLQRHEKI-HSREKPFGCDQCSMKF------------------------------------- 326

  Fly   489 RYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHEKRPLQC-DVCLK 552
                       ..||.:..|.::|:....|||..|.:.:|..::|.:|..|       | :|.:|
Human   327 -----------IQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRT-------CGEVIVK 373

  Fly   553 G 553
            |
Human   374 G 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	0/3 (0%)
		zf-C2H2	385..407	CDD:278523	11/21 (52%)
		C2H2 Zn finger	387..407	CDD:275368	11/19 (58%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	6/20 (30%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	3/19 (16%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	4/8 (50%)
		zf-met	574..597	CDD:289631
		C2H2 Zn finger	575..591	CDD:275368
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..149		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..253		16/81 (20%)
		C2H2 Zn finger	263..283	CDD:275368	11/19 (58%)
		zf-H2C2_2	275..300	CDD:316026	10/24 (42%)
		C2H2 Zn finger	291..311	CDD:275368	6/20 (30%)
		zf-H2C2_2	304..328	CDD:316026	10/72 (14%)
		C2H2 Zn finger	319..339	CDD:275368	7/67 (10%)
		zf-H2C2_2	331..356	CDD:316026	6/24 (25%)
		C2H2 Zn finger	347..366	CDD:275368	5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..427
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..817

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910