DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp553

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001347841.1	Gene:	Zfp553 / 233887	MGIID:	2384725	Length:	591	Species:	Mus musculus

Alignment Length:	385	Identity:	92/385 - (23%)
Similarity:	140/385 - (36%)	Gaps:	106/385 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 IEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQ--------DPLSVALGAKIFKELLDQYTGKE 332
            :|.:.||  |.|.:..::...|..:|...:|..|        |      |.:.:.:|.|:..|..
Mouse     1 MEASPGD--EFEHSPQERDGPEIKEEEQLAPTLQVGNTSLKPD------GIQCWDDLWDRREGLG 57

  Fly   333 KARLRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMS 397
            |.:.|...|         :..||.:..:.:|.:..                  ||.:||::||..
Mouse    58 KRQPRDPVP---------RILGEPRWGQGSNDRAA------------------VCGECGKSFRQM 95

  Fly   398 HNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMH---------IRIR------------------ 435
            .:|..|...||..|.|:|..|.|.|.|:..|..|         .|:|
Mouse    96 SDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHTGEKAYRVRPPAPGPPKMPRSRIPAGE 160

  Fly   436 ------------------------HRGETPFACGFCSETFAYPGARQKHESEVH--NAAPRLIVK 474
                                    |.||.|:.||.|.:.|....||.||: ..|  :..||.:|.
Mouse   161 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQ-RTHRGDQLPRPVVP 224

  Fly   475 RINPKP-------MPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNK 532
            |..|.|       .||.::. .|.|..|.|.:....:|..|.:||.....:.|..|.|.::..:.
Mouse   225 RRQPSPAAPAAPHRPKAQDK-PYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSD 288

  Fly   533 LKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSH 591
            |.:|...|. ::|..|..|.|||...:...:|...|:|:||:.|..||.:|.....:..|
Mouse   289 LVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRH 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	9/71 (13%)
		C2H2 Zn finger	444..460	CDD:275368	6/15 (40%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	5/18 (28%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Zfp553	NP_001347841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..80		6/33 (18%)
		C2H2 Zn finger	85..105	CDD:275368	7/19 (37%)
		zf-H2C2_2	97..120	CDD:316026	9/22 (41%)
		C2H2 Zn finger	113..133	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..160		2/28 (7%)
		COG5048	161..572	CDD:227381	51/190 (27%)
		C2H2 Zn finger	165..185	CDD:275368	0/19 (0%)
		C2H2 Zn finger	193..213	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..241		11/35 (31%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429
		C2H2 Zn finger	425..445	CDD:275368
		C2H2 Zn finger	453..538	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..512
		C2H2 Zn finger	546..566	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100