DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp51

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001295252.1	Gene:	Zfp51 / 22709	MGIID:	99198	Length:	781	Species:	Mus musculus

Alignment Length:	524	Identity:	132/524 - (25%)
Similarity:	210/524 - (40%)	Gaps:	140/524 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LSETVTMELDPLSGE-----EKLEELQKCRTCYNDFTADFRAKDLFDPAN---SVLLFHIEVISG 200
            :.||||.:....:||     ||.:|             |.:.:..:.|.|   .:|.|.
Mouse     1 MEETVTKDPASQAGESLYLKEKFKE-------------DKQKEMAYSPVNMPQGLLTFR------ 46

  Fly   201 VWISHKPDEPRLMCPACKSALDQAIDFRE---MCISTELKLSQAKPSTDEVQIEAEN-ENPISSD 261
                                 |.|:||.:   .|:.::.:...       :.:..|| .|.:|.:
Mouse    47 ---------------------DVAVDFPQEEWECLDSDQRALY-------IDVMLENYRNLVSVE 83

  Fly   262 HDLISDTENTNVE-EIEDAGGDHV----------------------------EDEATSDDQTSQE 297
            :..|.||.:.:|: |.|...|:.:                            .:|..|.|.::|.
Mouse    84 NYCICDTVHQHVKTEKESCQGNKLGEMLHEPSNCALYNRSDTTEASNKFRCCNNEDVSVDSSNQN 148

  Fly   298 AV------DEVAESPAAQDPLS----VALGAKIF------KELLDQYTGKEKARLRKGAPIASKP 346
            ..      :|..||...:..|:    ::...:::      :|:.|.|.....:.::..|.|..||
Mouse   149 RYKSTHTGEEPCESKDCEKSLTLCSDISQDQRLYNAKQHRQEVYDDYFSSAYSLMQPTAYIKEKP 213

  Fly   347 KAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTK 411
                    .|..|......|.....:..|...:.||  :.|..|.::|....:|:||..|||..|
Mouse   214 --------HQCGKCGKCFNTSSSLTVHHRIHTKEKP--YKCSVCDKSFTQCTHLKIHQRRHTGEK 268

  Fly   412 NYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFA-YPGAR--QK-HESEVHNAAPRL- 471
            .|:|.||.|:|........|.:: |.||.|:.|..|.::|| ||..|  || |.||.|.:.|..
Mouse   269 PYKCKECEKSFVQLSALKSHQKL-HTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECG 332

  Fly   472 --------IVKRINPKPMPKPRESVRYQCKLCQK---HYASKYALGWHIKSHTDANAYKCQRCSK 525
                    :.|........||     |:|..|.:   ||||   |.||.|:||....|:|:.|.|
Mouse   333 REFHQLSHLRKHYRLHTGEKP-----YKCNECDRSFTHYAS---LRWHQKTHTPEIHYECKECGK 389

  Fly   526 SYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMK 589
            |:.:.:.||||...|. ::|.:|::|.|.|...|.|:.|:.|||||:||.|..|:.:|.:..:::
Mouse   390 SFIELSHLKRHYRIHTGEKPYKCEICDKSFTTTTTLKTHQKIHTGEKPYKCRECDKSFIHSSHLR 454

  Fly   590 SHAN 593
            .|.|
Mouse   455 RHQN 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	10/78 (13%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	415..436	CDD:275368	6/20 (30%)
		C2H2 Zn finger	444..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	492..512	CDD:275368	10/22 (45%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	5/20 (25%)
		C2H2 Zn finger	575..591	CDD:275368	3/15 (20%)
Zfp51	NP_001295252.1	KRAB	42..82	CDD:366587	10/73 (14%)
		C2H2 Zn finger	216..236	CDD:275368	3/19 (16%)
		SFP1	<239..318	CDD:227516	30/81 (37%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..292	CDD:275368	6/20 (30%)
		C2H2 Zn finger	300..320	CDD:275368	9/19 (47%)
		COG5048	327..749	CDD:227381	47/140 (34%)
		C2H2 Zn finger	356..376	CDD:275368	10/22 (45%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	7/19 (37%)
		C2H2 Zn finger	440..460	CDD:275368	5/19 (26%)
		C2H2 Zn finger	468..488	CDD:275368
		C2H2 Zn finger	496..517	CDD:275368
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100