DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp40

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001344626.1	Gene:	Zfp40 / 22700	MGIID:	99185	Length:	796	Species:	Mus musculus

Alignment Length:	661	Identity:	146/661 - (22%)
Similarity:	249/661 - (37%)	Gaps:	164/661 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CGYTEESLKLKNPCICIEHFKDEDIEGSLKF---EMGLAKKRTLRP-------------GAVPCV 93
            ||..||.:...:..|..:|...|  |.|.|:   :..|.:.....|             |:....
Mouse    88 CGKYEEDMDQSSNHIIYQHANIE--EKSYKYHELDKMLYESSQSTPYNTSDTTENCKMYGSDNQW 150

  Fly    94 NKSQESGSDRARKERSQRRRNQELVAELL--------------AEEEAKLIHPEATSFEQDSVYL 144
            :.|.||.:.:|.|.||......:...|.|              .::|.|:.       |.|..:.
Mouse   151 DPSNESLNLKAHKSRSTEEEEYKDYREYLNLCSIIGSYTQMDTRKKEHKIT-------EHDKFFD 208

  Fly   145 SETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAK---------DLFDPANSVL-LFHIEVIS 199
            |:...|.....|| ||..:.:||..|:..:::.:|.:         .|.:...|:| |.|.:|..
Mouse   209 SKHKLMIKRMCSG-EKPYQCRKCGKCFRTYSSLYRHRRTHPGEKPYKLTECNKSILYLSHHKVHY 272

  Fly   200 GVWISHKPDEPRLMCPAC--KSALDQAIDFREMCISTELKLSQAKPSTDEVQIEAENENPISSD- 261
            .:....||.: .:.|..|  .|:.::                       ..:|.:|.|:...:|
Mouse   273 NIHYGEKPYK-CIECGKCYYHSSFEK-----------------------HYRIHSEEESYKCNDC 313

  Fly   262 ------------HDLISDTENTNVEEIEDAG-----GDHVEDEATSDDQ---TSQEAVDEVAESP 306
                        |..|...|..  .|.:...     ..|:|:...:..:   ...|....::.|.
Mouse   314 RKSFICCLGLKRHHKIHGGERP--YECKQCSKSFYTSSHLENHYRTHRRKLHRCNECGKSLSSSS 376

  Fly   307 AAQDPLSVALGAKIF-----------KELLDQ----YTGKEK---ARLRKGAPIASKPKAKEKAA 353
            ..|....:..|.|.:           |..|..    :||::.   :...|...:.|..:..::..
Mouse   377 GLQRHQRIHRGEKAYICAECNKCFIQKSQLKTHQRIHTGEKSYKCSECEKSFTVGSSLRIHQRIH 441

  Fly   354 GEQKPKRSANPKTKEERNLIRRAQLR--------AKPPNFVCDQCGQAFRMSHNLRIHMLRHTRT 410
            ..:||.:.    ::..:..|::|.||        .||  :.|.:|.::|.:..:||:|...||..
Mouse   442 TGEKPYKC----SECHKCFIQQAHLRRHQKIHTGEKP--YKCSECEKSFTVGSDLRMHQKIHTGE 500

  Fly   411 KNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVH--------NA 467
            |.|:|::|.|.|........|.|| |.||.|:.|..|.:.|......:.|: ::|        :.
Mouse   501 KPYKCSDCDKCFIQKAKLKKHQRI-HTGEKPYKCSECEKCFTVVSDLRTHQ-KIHTGEKPYKCSE 563

  Fly   468 APRLIVKRIN----------PKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQR 522
            ..:..:::.|          .||         |:|..|.|.:..|..|..|.:.||....|||:
Mouse   564 CDKCFIRKANLRRHHRIHTGEKP---------YKCSDCGKCFIQKANLRTHERIHTGEKPYKCE- 618

  Fly   523 CSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKY 586
            |.||::..:.|::|:..|. ::|.:|..|.|.|.::..||.|:.|||||:||.|..|...|..|.
Mouse   619 CGKSFTVGSDLRKHQKCHTGEKPYKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCGKCFIQKA 683

  Fly   587 NMKSHANSKMH 597
            |:::|  .|:|
Mouse   684 NLRTH--QKIH 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	13/66 (20%)
		zf-AD	167..240	CDD:214871	14/84 (17%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	7/22 (32%)
		C2H2 Zn finger	575..591	CDD:275368	5/15 (33%)
Zfp40	NP_001344626.1	KRAB	42..82	CDD:307490
		C2H2 Zn finger	227..247	CDD:275368	4/19 (21%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		COG5048	279..677	CDD:227381	98/441 (22%)
		C2H2 Zn finger	283..302	CDD:275368	3/41 (7%)
		C2H2 Zn finger	310..330	CDD:275368	2/19 (11%)
		C2H2 Zn finger	338..358	CDD:275368	2/19 (11%)
		C2H2 Zn finger	365..385	CDD:275368	3/19 (16%)
		C2H2 Zn finger	393..413	CDD:275368	2/19 (11%)
		C2H2 Zn finger	421..441	CDD:275368	2/19 (11%)
		C2H2 Zn finger	449..469	CDD:275368	4/23 (17%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	533..553	CDD:275368	4/20 (20%)
		C2H2 Zn finger	561..581	CDD:275368	1/19 (5%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		C2H2 Zn finger	618..636	CDD:275368	5/18 (28%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	672..692	CDD:275368	7/21 (33%)
		zf-H2C2_2	684..709	CDD:316026	4/11 (36%)
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100