DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and ZNF585A

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001275729.1	Gene:	ZNF585A / 199704	HGNCID:	26305	Length:	769	Species:	Homo sapiens

Alignment Length:	606	Identity:	147/606 - (24%)
Similarity:	211/606 - (34%)	Gaps:	171/606 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RFPKCPDTFKAWLAFCGYTEES-LKL-------KNPCICIE---------HFKDEDIEGSLKFEM 77
            |..:|.|..||      :|::| ||:       :...||||         |
Human   240 RHHECTDCGKA------FTQKSTLKMHQKIHTGERSYICIECGQAFIQKTH-------------- 284

  Fly    78 GLAKKRTLRPGAVP--CVN--KSQESGSDRARKERSQRRRNQELVAE---LLAEEEAKLIHPEAT 135
             |...|.:..|..|  |.|  ||..|.|.....:|...|....:..|   :.:.....:.|.:..
Human   285 -LIAHRRIHTGEKPYECSNCGKSFISKSQLQVHQRVHTRVKPYICTEYGKVFSNNSNLVTHKKVQ 348

  Fly   136 SFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISG 200
            |.|:.|:                        |..|...||  :|         |.|:.|..:.:|
Human   349 SREKSSI------------------------CTECGKAFT--YR---------SELIIHQRIHTG 378

  Fly   201 VWISHKPDEPRLMCPAC------KSAL--DQAIDFRE---MCISTELKLSQAKPSTDEVQIEAEN 254
                .||.|    |..|      ||||  .|.|...|   :|:...|...| |......||....
Human   379 ----EKPYE----CSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQ-KAHLIAHQIIHTG 434

  Fly   255 ENPISSDH--DLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLSVALG 317
            |.|....|  .|.:.....:|.:....|                            :.|......
Human   435 EKPHKCGHCGKLFTSKSQLHVHKRIHTG----------------------------EKPYMCNKC 471

  Fly   318 AKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKP 382
            .|.|....:..| .:|....:.:.|.||       .|:...:||         :||...::....
Human   472 GKAFTNRSNLIT-HQKTHTGEKSYICSK-------CGKAFTQRS---------DLITHQRIHTGE 519

  Fly   383 PNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFC 447
            ..:.|:.||:||....:|.||...||..:.|:|.||.|.|....:..:|.:| |.||.|:.|..|
Human   520 KPYECNTCGKAFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKI-HTGEKPYVCTEC 583

  Fly   448 SETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSH 512
            ...|.     :|.....|        :||:....|       |:|..|.|.:.||..|..|...|
Human   584 GRAFI-----RKSNFITH--------QRIHTGEKP-------YECSDCGKSFTSKSQLLVHQPVH 628

  Fly   513 TDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCE 576
            |....|.|..|.|::|..:.|.:|:.||. ::|..|..|.|.|.|::.|..|..|||||:||.|.
Human   629 TGEKPYVCAECGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELITHHRIHTGEKPYECS 693

  Fly   577 VCNVNFRYKYNMKSHANSKMH 597
            .|..:|..|..::.|  .::|
Human   694 DCGKSFTKKSQLQVH--QRIH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	20/86 (23%)
		zf-AD	167..240	CDD:214871	23/83 (28%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	5/22 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
ZNF585A	NP_001275729.1	C2H2 Zn finger	748..768	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		COG5048	184..529	CDD:227381	79/398 (20%)
		C2H2 Zn finger	188..208	CDD:275368
		zf-H2C2_2	200..225	CDD:290200
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368	8/25 (32%)
		C2H2 Zn finger	272..292	CDD:275368	6/34 (18%)
		zf-H2C2_2	284..309	CDD:290200	9/39 (23%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	328..347	CDD:275370	2/18 (11%)
		C2H2 Zn finger	356..376	CDD:275368	8/30 (27%)
		zf-H2C2_2	368..393	CDD:290200	8/32 (25%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		C2H2 Zn finger	412..432	CDD:275368	6/20 (30%)
		C2H2 Zn finger	440..460	CDD:275368	3/19 (16%)
		zf-H2C2_2	455..477	CDD:290200	5/49 (10%)
		C2H2 Zn finger	468..488	CDD:275368	4/20 (20%)
		COG5048	476..768	CDD:227381	80/277 (29%)
		C2H2 Zn finger	496..516	CDD:275368	7/35 (20%)
		zf-H2C2_2	508..533	CDD:290200	7/24 (29%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..572	CDD:275368	7/20 (35%)
		C2H2 Zn finger	580..600	CDD:275368	6/32 (19%)
		zf-H2C2_2	592..617	CDD:290200	8/39 (21%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-H2C2_2	648..673	CDD:290200	9/24 (38%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		zf-H2C2_2	676..700	CDD:290200	11/23 (48%)
		C2H2 Zn finger	692..712	CDD:275368	5/21 (24%)
		zf-H2C2_2	705..728	CDD:290200	2/10 (20%)
		C2H2 Zn finger	720..740	CDD:275368
		zf-H2C2_2	732..757	CDD:290200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100