DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and ZNF48

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001201835.1	Gene:	ZNF48 / 197407	HGNCID:	13114	Length:	618	Species:	Homo sapiens

Alignment Length:	401	Identity:	104/401 - (25%)
Similarity:	156/401 - (38%)	Gaps:	71/401 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 KPSTDEVQIEAE----NENPISSDHDLISDTENTNVEE-----IEDAGGDHVEDEATSDDQTSQE 297
            :|...|.|..|.    :||.||..::.    |:|..|:     .||...||....|:...:..|.
Human    14 RPEEREPQRGARTGLGSENVISQPNEF----EHTPQEDDLGFKEEDLAPDHEVGNASLKPEGIQN 74

  Fly   298 AVD-----EVAESPAAQDPLSVALG------------------AKIFKELLD------QYTGKEK 333
            ..|     |....|..:|.....||                  .|.|:::.|      .:||::.
Human    75 WDDLWVQREGLGKPQPRDRGPRLLGEPRWGQASSDRAAVCGECGKSFRQMSDLVKHQRTHTGEKP 139

  Fly   334 AR---LRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFR 395
            .:   ..||...:|.....::....:||.|:..|.....:  |.|:::.|.....:|.:||::||
Human   140 YKCGVCGKGFGDSSARIKHQRTHSGEKPYRARPPAQGPPK--IPRSRIPAGERPTICGECGKSFR 202

  Fly   396 MSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKH 460
            .|.:|..|...||..|.|:|..|.|.|.|:..|..|.| .||||.|          ..|...::.
Human   203 QSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQR-THRGEQP----------PRPVVPRRQ 256

  Fly   461 ESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSK 525
            .|....||.:      .||...||     |.|..|.|.:....:|..|.:||.....:.|..|.|
Human   257 PSRAATAATQ------GPKAQDKP-----YICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGK 310

  Fly   526 SYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMK 589
            .::..:.|.:|...|. ::|..|..|.|||...:...:|...|:||||:.|..|:..|.....:.
Human   311 EFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLSSTLL 375

  Fly   590 SHANSKMH-QD 599
            .|..:.|. ||
Human   376 RHRLTHMEPQD 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	1/15 (7%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	4/22 (18%)
		C2H2 Zn finger	575..591	CDD:275368	3/15 (20%)
ZNF48	NP_001201835.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..109		5/30 (17%)
		zf-C2H2	113..134	CDD:278523	3/20 (15%)
		COG5048	114..499	CDD:227381	81/297 (27%)
		C2H2 Zn finger	114..134	CDD:275368	3/19 (16%)
		zf-H2C2_2	126..149	CDD:290200	4/22 (18%)
		C2H2 Zn finger	142..162	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189		7/33 (21%)
		C2H2 Zn finger	194..214	CDD:275368	8/19 (42%)
		zf-C2H2	194..214	CDD:278523	8/19 (42%)
		zf-H2C2_2	206..229	CDD:290200	9/22 (41%)
		C2H2 Zn finger	222..242	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..271		14/52 (27%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..325	CDD:275368	5/19 (26%)
		zf-H2C2_2	317..341	CDD:290200	8/23 (35%)
		C2H2 Zn finger	333..353	CDD:275368	6/19 (32%)
		zf-H2C2_2	348..369	CDD:290200	8/20 (40%)
		C2H2 Zn finger	361..381	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..457
		zf-C2H2	451..473	CDD:278523
		C2H2 Zn finger	453..473	CDD:275368
		zf-H2C2_2	465..489	CDD:290200
		C2H2 Zn finger	481..501	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..540
		COG5048	524..>591	CDD:227381
		zf-C2H2	543..565	CDD:278523
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..580	CDD:290200
		C2H2 Zn finger	573..593	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100