DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and ZNF836

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001096127.1	Gene:	ZNF836 / 162962	HGNCID:	34333	Length:	936	Species:	Homo sapiens

Alignment Length:	507	Identity:	120/507 - (23%)
Similarity:	199/507 - (39%)	Gaps:	132/507 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VAELLAEEEAKLIHPEATSFEQDSV-----------YLSETVTMELDPLSGEEKLEELQKCRT-- 169
            ||...::||.|.:.|...:...|.:           .|.:.:|.||.|:......|   ||:|
Human    13 VAIEFSQEEWKSLDPVQKALYWDVMLENYRNLVFLGILPKCMTKELPPIGNSNTGE---KCQTVT 74

  Fly   170 -----CYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFRE 229
                 ||:  ..:|..:::..        :::.:...|                  .|..|:::|
Human    75 LERHECYD--VENFYLREIQK--------NLQDLEFQW------------------KDGEINYKE 111

  Fly   230 --MCISTELKLSQAKPSTDEVQIEA-ENENPISSDHDLISDTENTNVEEIEDAGGDHV--EDEAT 289
              |.....|...:.:.|.::|:.:. ||:..:|....|      |.:::.:..|..:.  :.|.|
Human   112 VPMTYKNNLNGKRGQHSQEDVENKCIENQLTLSFQSRL------TELQKFQTEGKIYECNQSEKT 170

  Fly   290 SDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAG 354
            .::.:....:..:.  |:.|..:|    .|...|.|.                .|.|...||
Human   171 VNNSSLVSPLQRIL--PSVQTNIS----KKYENEFLQ----------------LSLPTQLEK--- 210

  Fly   355 EQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECP 419
                                 ..:|.||  ::|..||:|||:|.:|..|.:.||..|.|:|.||.
Human   211 ---------------------THIREKP--YMCKGCGKAFRVSSSLINHQMVHTTEKPYKCNECG 252

  Fly   420 KTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKP 484
            |.|:...:..:|..:..||: |:.||.|.:.|     ||..:...|..:      ....||
Human   253 KAFHRGSLLTIHQIVHTRGK-PYQCGVCGKIF-----RQNSDLVNHRRS------HTGEKP---- 301

  Fly   485 RESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCD 548
                 |:|..|.|.::..|.|..|.:.||....|||..|.|::...:.|..|::.|. ::|.|||
Human   302 -----YKCNECGKSFSQSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTHQIIHTGEKPYQCD 361

  Fly   549 VCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMHQDN 600
            :|.|.|.|.:.|..|:.|||||:||.|.:|..:|....|:.:|  ..:|..|
Human   362 ICGKVFRQNSNLVNHQRIHTGEKPYKCNICGKSFSQSSNLATH--QTVHSGN 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	11/81 (14%)
		zf-C2H2	385..407	CDD:278523	9/21 (43%)
		C2H2 Zn finger	387..407	CDD:275368	9/19 (47%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	6/20 (30%)
		C2H2 Zn finger	444..460	CDD:275368	6/15 (40%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	5/22 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
ZNF836	NP_001096127.1	KRAB	8..>48	CDD:214630	7/34 (21%)
		KRAB	8..47	CDD:279668	7/33 (21%)
		C2H2 Zn finger	220..240	CDD:275368	9/19 (47%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		COG5048	272..648	CDD:227381	51/163 (31%)
		C2H2 Zn finger	276..296	CDD:275368	7/30 (23%)
		zf-H2C2_2	288..313	CDD:290200	7/39 (18%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		zf-H2C2_2	316..341	CDD:290200	9/24 (38%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	345..369	CDD:290200	10/23 (43%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..397	CDD:290200	12/24 (50%)
		C2H2 Zn finger	388..408	CDD:275368	5/21 (24%)
		zf-H2C2_2	400..425	CDD:290200	4/14 (29%)
		C2H2 Zn finger	416..436	CDD:275368
		zf-H2C2_2	428..453	CDD:290200
		C2H2 Zn finger	444..464	CDD:275368
		zf-H2C2_2	457..481	CDD:290200
		C2H2 Zn finger	472..492	CDD:275368
		zf-H2C2_2	484..509	CDD:290200
		COG5048	496..904	CDD:227381
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..548	CDD:275368
		zf-H2C2_2	541..565	CDD:290200
		C2H2 Zn finger	556..576	CDD:275368
		zf-H2C2_2	568..593	CDD:290200
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	597..620	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
		zf-H2C2_2	653..677	CDD:290200
		C2H2 Zn finger	668..688	CDD:275368
		C2H2 Zn finger	696..714	CDD:275370
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		zf-H2C2_2	764..789	CDD:290200
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	793..815	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
		zf-H2C2_2	821..843	CDD:290200
		C2H2 Zn finger	836..856	CDD:275368
		zf-H2C2_2	849..873	CDD:290200
		C2H2 Zn finger	864..884	CDD:275368
		zf-H2C2_2	877..899	CDD:290200
		C2H2 Zn finger	892..912	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010