DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Znf48

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_008758156.1	Gene:	Znf48 / 103690203	RGDID:	9115869	Length:	590	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	95/379 - (25%)
Similarity:	140/379 - (36%)	Gaps:	105/379 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 VDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIAS---KPK---------AKEK 351
            |||...:|..:|      |.:.          ||:.:|..|..:.:   ||:         .:.:
  Rat     6 VDEFEHTPQERD------GPEF----------KEEEQLGPGHEVGNASLKPEGIQSWDDLWVRRE 54

  Fly   352 AAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCT 416
            ..|:.:| |.|.|:...|....:.:..||.    ||.:||::||...:|..|...||..|.|:|.
  Rat    55 GLGKHQP-RDAVPRVLGEPRWGQGSNDRAA----VCGECGKSFRQMSDLVKHQRTHTGEKPYKCG 114

  Fly   417 ECPKTFYDAYMRNMH---------IRIR------------------------------------- 435
            .|.|.|.|:..|..|         .|:|
  Rat   115 VCGKGFGDSSARIKHQRTHTGEKPYRVRPPAPGPPKMPRSRIPAGERPTICGECGKSFRQSSDLV 179

  Fly   436 -----HRGETPFACGFCSETFAYPGARQKHESEVH--NAAPRLIVKR-----------INPKPMP 482
                 |.||.|:.||.|.:.|....||.||: ..|  :..||.:|.|           ..||...
  Rat   180 KHQRTHTGEKPYKCGICGKGFGDSSARIKHQ-RTHRGDQLPRPVVPRRQPSQAAPEATHRPKAQD 243

  Fly   483 KPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQ 546
            ||     |.|..|.|.:....:|..|.:||.....:.|..|.|.::..:.|.:|...|. ::|..
  Rat   244 KP-----YICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYL 303

  Fly   547 CDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMH-QD 599
            |..|.|||...:...:|...|:|:||:.|..||.:|.....:..|..:.|. ||
  Rat   304 CPECGKGFADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRHRLTHMEPQD 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	9/71 (13%)
		C2H2 Zn finger	444..460	CDD:275368	6/15 (40%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	5/22 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Znf48	XP_008758156.1	zf-C2H2	84..105	CDD:278523	8/20 (40%)
		COG5048	85..471	CDD:227381	74/279 (27%)
		C2H2 Zn finger	85..105	CDD:275368	7/19 (37%)
		zf-H2C2_2	97..120	CDD:290200	9/22 (41%)
		C2H2 Zn finger	113..133	CDD:275368	7/19 (37%)
		C2H2 Zn finger	165..185	CDD:275368	0/19 (0%)
		zf-C2H2	165..185	CDD:278523	0/19 (0%)
		zf-H2C2_2	177..200	CDD:290200	7/22 (32%)
		C2H2 Zn finger	193..213	CDD:275368	8/20 (40%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		zf-H2C2_2	288..312	CDD:290200	8/23 (35%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..340	CDD:290200	8/20 (40%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-C2H2	423..445	CDD:278523
		C2H2 Zn finger	425..445	CDD:275368
		zf-H2C2_2	437..461	CDD:290200
		C2H2 Zn finger	453..537	CDD:275368
		COG5048	495..>563	CDD:227381
		zf-C2H2	515..537	CDD:278523
		zf-H2C2_2	529..552	CDD:290200
		C2H2 Zn finger	545..565	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100