DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp605

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_017454057.1	Gene:	Zfp605 / 100365779	RGDID:	2318406	Length:	756	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	129/561 - (22%)
Similarity:	213/561 - (37%)	Gaps:	150/561 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NQEL---VAELLAEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFT 175
            ||.:   ||..|.:||::::..|..:.....::|:.  ..|..|...::||:.:::       ..
  Rat    48 NQTIKPDVAFKLDQEESRIMDEEILTQNFLEIWLNS--NSEPWPQDKQDKLKRMER-------GN 103

  Fly   176 ADFRAKDLFDPA-NSVLL---FHIEVISGVWISHKPDEPRLMCPACKSALDQAIDF---REMCIS 233
            .|...:.||.|: |||.|   |||                  |...:..:...::|   :..|..
  Rat   104 GDNVLEKLFQPSMNSVYLEMRFHI------------------CGTSEKNVKNPLNFFILKSNCGR 150

  Fly   234 TELKLSQAKPSTDEVQIEAENENPISSD--HDLISDTE-NTNVEEIEDAGGDHVEDEATSD---- 291
            .:.|:|:      ::....:.:...|..  ||.....: |:|..::       |.::.|..
  Rat   151 IKSKVSK------KLLFYLKFDRSYSKRKFHDCNKYRKANSNESQL-------VTNQMTHSGIYL 202

  Fly   292 --------DQTSQEAV---DEVAESP---------AAQDPLSVALGAKIFK-------ELLDQYT 329
                    ::.||..|   :...|.|         .||..| :||..|...       |....::
  Rat   203 CMECGRIFNKKSQLTVHQRNHTGEKPYQCNGCGKTFAQKSL-LALHQKSHSVEPDGCDERQKAFS 266

  Fly   330 GK----EKARLRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQC 390
            ||    ::.|...|..:.:..||..:               |.::|.........||  :.|..|
  Rat   267 GKSLVIQQQRTHAGQKLCTHGKAYSR---------------KSQQNRQEMIHTMGKP--YRCSDC 314

  Fly   391 GQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPG 455
            |:||.....|.||...||..|.|:|:||.|.|:.......|.| .|||:.|:.|..|.:.|....
  Rat   315 GKAFSQKLKLIIHRRTHTGEKPYKCSECRKAFFWNSQLITHQR-SHRGKKPYVCSKCKKAFRRNS 378

  Fly   456 ARQKHESEVHNAAPRLIVKRINPKPMPKPRES-------VR----------------YQCKLCQK 497
            ...:|: .:|              .:.||:.|       :|                |||..|::
  Rat   379 LLIRHQ-RIH--------------AVEKPQRSRECGEAFIRKAQLTKHRMTHTGEKSYQCYDCEE 428

  Fly   498 HYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTH-EKRPLQCDVCLKGFYQRTRLR 561
            .:..|..|..|.|||......:|..|.|::.:.::|..|:.:| |:|||:|..|.|.|.::.:|.
  Rat   429 AFFKKSQLMRHQKSHLGERPLRCTECGKTFPEKSQLLTHQKSHLEERPLRCTECGKTFPEKLQLL 493

  Fly   562 EHELIHTGERPYWCEVCNVNFRYKYNM----KSHANSKMHQ 598
            .|:..|.||||:.|..|...|..|..:    |||...:.|:
  Rat   494 THQKSHLGERPHRCTECGKTFPEKLQLLTHQKSHLGERPHR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	15/79 (19%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	11/22 (50%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	7/26 (27%)
		C2H2 Zn finger	575..591	CDD:275368	5/19 (26%)
Zfp605	XP_017454057.1	KRAB	8..63	CDD:214630	5/14 (36%)
		KRAB	8..46	CDD:279668
		C2H2 Zn finger	177..197	CDD:275368	3/26 (12%)
		COG5048	<200..355	CDD:227381	39/172 (23%)
		C2H2 Zn finger	203..223	CDD:275368	3/19 (16%)
		zf-H2C2_2	216..240	CDD:290200	3/23 (13%)
		C2H2 Zn finger	231..251	CDD:275368	6/20 (30%)
		C2H2 Zn finger	287..303	CDD:275368	4/30 (13%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		zf-H2C2_2	324..346	CDD:290200	11/21 (52%)
		C2H2 Zn finger	339..359	CDD:275368	7/20 (35%)
		COG5048	362..750	CDD:227381	49/188 (26%)
		C2H2 Zn finger	367..387	CDD:275368	4/20 (20%)
		C2H2 Zn finger	395..415	CDD:275368	2/19 (11%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		C2H2 Zn finger	535..555	CDD:275368	129/561 (23%)
		zf-H2C2_2	548..572	CDD:290200
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	578..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		zf-H2C2_2	603..627	CDD:290200
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		zf-H2C2_2	688..712	CDD:290200
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100